The integrated strategy for schistosomiasis control with focus on infectious source control，which has been imple? mented since 2004，accelerated the progress towards schistosomiasis control in China，and achieved transmission control of the disease across the country by the end of 2015，which achieved the overall objective of the Mid? and Long?term National Plan for Prevention and Control of Schistosomiasis（2004-2015）on schedule. Then, the goal of schistosomiasis elimination by 2025 was proposed in China in 2014. To achieve this new goal on schedule, we have to address the key issues, and implement precision control measures with more precise identification of control targets, so that we are able to completely eradicate the po? tential factors leading to resurgence of schistosomiasis transmission and enable the achievement of schistosomiasis elimination on schedule. Precision schistosomiasis control，a theoretical innovation of precision medicine in schistosomiasis control，will pro? vide new insights into schistosomiasis control based on the conception of precision medicine. This paper describes the definition， interventions and the role of precision schistosomiasis control in the elimination of schistosomiasis in China，and demonstrates that sustainable improvement of professionals and integrated control capability at grass ?root level is a prerequisite to the imple? mentation of schistosomiasis control，precision schistosomiasis control is a key to the further implementation of the integrated strategy for schistosomiasis control with focus on infectious source control, and precision schistosomiasis control is a guarantee of curing schistosomiasis patients and implementing schistosomiasis control program and interventions.