Clonorchiasis is one of the food?borne parasitic diseases. Adult parasites live in the human liver and gallbladder tube system，causing serious complications，such as gallstones，cholecystitis and cholangitis，and even bile duct cancer. The disease is very popular in our country，and the population infection rate is high. It is an important public health problem. Guang? dong Province is the earliest province being found of clonorchiasis and with serious epidemic. In the second national human para? sitic diseases distribution survey，the results showed that the average infection rate of Clonorchis sinensis in the epidemic areas in Guangdong was 16.42%. It is estimated that the population of C. sinensis infection is over 500 million. The prevention and con? trol of clonorchiasis in China is still in the initial stage currently and we face many challenges such as unclear epidemic charac? teristics and transmission mode，and lack of long?term prevention and control mechanism. This article introduces the epidemic situation of clonorchiasis and prevention and control strategies and measures in Guangdong.