Abstract: Objective Objective To evaluate the effect of the clinical nursing path integrated with the holistic nursing on advanced schistosomiasis patients with ascites. Methods Methods A total of 226 advanced schistosomiasis patients with ascites were randomly di? vided into a control group and an experimental group（113 cases each group） . The subjects in the experimental group were nursed by the clinical nursing path integrated with the holistic nursing，while those in the control group were nursed only by the holistic nursing. Then the clinical relevant indexes of the two groups were observed，and the quality of life of the patients before and after hospital discharge was assessed. Results Results The improvement rate，satisfaction degree，and awareness rate of health knowledge of the patients in the experiment group were 93.8%，100% and 97.4%，respectively，which were significantly higher than those of the control group（all P < 0.05） . The mortality rate and the complication rate of the patients in the experimental group were 0 and 2.7%，respectively，which were significantly lower than those of the control group（both P < 0.05） . In addi? tion，the average hospitalization days and the hospitalization cost of the experiment group were（12.2 ± 0.7）d and （4 725.0 ± 310.1） Yuan respectively，which were less than those of the control group（both P < 0.01） . When 6 months after the discharge from hospital，the quality of life of the patients in the experimental group in various fields was significantly better than that of the control group （all P < 0.05） . Conclusions Conclusions The clinical nursing pathway integrated with holistic nursing can effectively improve the improvement rate and decrease the mortality of the advanced schistosomiasis patients with ascites；meanwhile，it can short? en the hospitalization time and save the hospitalization cost. Therefore，this nursing model is suitable for popularization and ap? plication in the treatment and nursing work of the advanced schistosomiasis assistance.

Key words: Advanced schistosomiasis, Ascitic type, Clinical nursing path, Holistic nursing, Clinical index, Quality of life

摘要： 目的 目的 评价晚期血吸虫病 （晚血） 腹水型患者临床护理路径 （CNP） 与整体护理整合的效果。方法 方法 将226例晚 血腹水型患者随机分为观察组与对照组， 每组113例。观察组实施CNP整合整体护理， 对照组实施整体护理。观察两组 患者的临床相关指标， 并对其出院前后的生存质量进行评估。结果 结果 观察组患者好转率、 满意度、 健康知识知晓率分别 为93.8%、 100%、 97.4%， 均明显高于对照组， 差异均有统计学意义 （P均 < 0.05）； 病死率为0， 并发症发生率为2.7%， 均低 于对照组， 差异均有统计学意义 （P均 < 0.05）； 住院时间为 （12.2 ± 0.7）d， 住院费用为 （4 725.0 ± 310.1） 元， 均低于对照 组， 差异均有统计学意义 （P均 < 0.01）。出院后6个月， 观察组患者各领域生存质量明显好于对照组， 差异均有统计学意 义 （P均 < 0.05）。结论 结论 CNP整合整体护理能提高晚血腹水型患者的好转率、 降低病死率， 并能缩短住院时间， 节省住院 费用。此护理模式适宜在血防专科医院晚血救治临床护理工作中推广应用。

关键词: 晚期血吸虫病, 腹水型, 临床护理路径, 整体护理, 临床指标, 生存质量