Objective To understand the natural infection status of Angiostrongylus cantonensis in snails Achatina fulica and Pomacea canaliculata from Panyu region of Guangzhou City. Methods The snails Achatina fulica and Pomacea canaliculata cap? tured from the field were digested with the artificial stomach fluid. The third? stage larvae of A. cantonensis were examined and counted under a microscope. The collected third?stage larvae were used to infect SD rats. Results A total of 367 Achatina fulica and 357 Pomacea canaliculata were examined. The infection rate of A. cantonensis in Achatina fulica was 22.62%，with a mean in? tensity of 57.00 larvae per positive snail. The infection rate of A. cantonensis in Pomacea canaliculata was 3.08%，with a mean in? tensity of 1.64 larvae per positive snail. The infection rates of A. cantonensis in Achatina fulica from Dagang，Shiqi，Hualong，and Lanhe towns and Nansha District，were 13.33%，15.00%，20.93%，73.68% and 8.41%，respectively. Those in Pomacea canalic? ulata were 5.88%，2.88%，1.89%，0% and 3.96%，respectively. Conclusions A. cantonensis infection exists in Achatina fulica and Pomacea canaliculata from Panyu region of Guangzhou City，and the infection in Achatina fulica is more serious than that in Pomacea canaliculata. The infection rates of the snails among five sites are different.