Abstract: ES⁃62 is a phosphorylcholine⁃containing, 62 kDa glycoprotein derived from the excretory⁃secretory product of Acanthocheilonema viteae, which is effective for the prevention and treatment of immune dysregulation diseases through triggering activation of immune cells, such as dendritic cells, mononuclear macrophages and regulatory B cells and mediating immune responses. Recently, the role of the ES⁃62 protein in the management of allergic, autoimmune and metabolic diseases has been paid much attention. This review summarizes the regulatory role of the ES⁃62 protein in immune dysregulation diseases and the underlying mechanisms, so as to provide insights into future experimental studies.

Key words: Acanthocheilonema viteae, Excretory?secretory product, ES?62, Immune dysregulation diseases

摘要： ES⁃62（excretory secretory⁃62）是源自魏氏棘唇线虫（Acanthocheilonema viteae）排泄分泌物中的一种由磷酰胆碱修饰的四聚体糖蛋白，可通过诱导树突状细胞、单核⁃巨噬细胞和调节性B细胞等免疫细胞耐受介导免疫调节反应，以预防或治疗免疫失调性疾病。近年来，ES⁃62蛋白在过敏性、自身免疫性及代谢性疾病等多种免疫失调性疾病中的作用成为研究热点。本文综述了ES⁃62蛋白在各种免疫失调性疾病中的调节作用及相关机制，为进一步研究提供理论依据及实验参考。

关键词: 魏氏棘唇线虫, 排泄分泌物, ES?62, 免疫失调性疾病