Objective To evaluate the role of new strategy in the transmission control of schistosomiasis in Poyang Lake region. Methods The information and epidemic data of schistosomiasis control were collected and analyzed in Poyang Lake region from 2005 to 2016. Results After eleven years of carrying out the new strategy， thirteen counties achieved the objective of transmission control in Poyang Lake region. In 2016， the number of schistosomiasis cases and human infection rate were 10 301 and 0.03%， decreased by 89.64% and 99.45% compared with those in 2005， respectively. The number of cattle and schistosome?infected cattle were 68 152 and 5， decreased by 50.84% and 99.83% compared with those in 2005， respectively. The average density of Oncomelania hupensis snails was decreased by 61.52%. No schistosome?infected snails were found since 2014. Conclusion The new strategy accurately locates the key points and targets of schistosomiasis transmission chain， which has controlled the human and animal’s fecal eggs from polluting grassland， and cut off the transmission chain， reduced both the infection rates of human and animal and the re?infection risk， and promoted to achieve the target of schistosomiasis transmission control in Poyang Lake region.