Abstract: Objective To investigate the Toxoplasma gondii infection status in pregnant women with history of adverse pregnancy and risk factors in Bazhou area， Hebei Province. Methods A total of 302 pregnant women with the history of adverse pregnancy were chosen as respondents （an experimental group） in the hospital from March 2012 to December 2015， and 197 pregnant women without the history of adverse pregnancy as a control group. TOX?IgG and TOX?IgM were detected by using ELISA in two groups. The risk factors of Toxoplasma infection were surveyed by questionnaires. Results The total positive rate of Toxoplasma antibodies was 28.15% （85/302） in the experimental group， which was significantly higher than that ［9.64% （19/197）］ in the control group， and the difference was statistically significant （[χ2]= 24.76， P＜0.05）. The positive rates of TOX?IgM， TOX?IgG and TOX?IgM + TOX?IgG were 6.95% （21/302）， 18.54% （56/302）， and 2.65% （8/302） respectively in the experimental group， which were higher than 2.03% （4/197）， 7.61% （15/197）， and 0% （0/197） respectively in the control group （[χ2]= 6.07， 11.67， 3.76， all P＜0.05）. The questionnaire survey showed that the proportions of keeping pets， cutting board regardless， liking to eat hot pot or barbecue， eating raw meat， often eating in the restaurant in the pregnant women with Toxoplasma infection were higher than those in the pregnant women without Toxoplasma infection， and the differences were statistically significant （[χ2]= 22.57， 3.96， 5.87， 7.40， 4.86， all P＜0.05）， and therefore， the above unhealthy habits may be important risk factors. Conclusions Toxoplasma infection could lead to adverse pregnancy outcomes. Therefore， the above?mentioned unhealthy habits should be avoided， especially during pregnancy period.

Key words: Toxoplasma gondii； Infection； Adverse pregnancy； Risk factor； Bazhou area； Hebei Province

摘要： 目的 调查河北省霸州地区不良妊娠史孕妇弓形虫感染状况及其危险因素。方法 选择2012年3月至2015年12月廊坊市第四人民医院妇产科接诊的不良妊娠史孕妇302例为调查对象（实验组），正常对照组为产前检查无异常妊娠史的孕妇197例。采用酶联免疫吸附法检测2组孕妇血清弓形虫IgG（TOX?IgG）和IgM抗体（TOX?IgM）含量。同时，对2组孕妇进行弓形虫感染危险因素问卷调查。收集整理数据并进行统计分析。结果 实验组弓形虫抗体总阳性率为28.15%（85/302），对照组总阳性率为9.64%（19/197），差异有统计学意义（[χ2]= 24.76，P < 0.05）。其中实验组TOX?IgM阳性率为6.95%（21/302），TOX?IgG阳性率为18.54%（56/302），TOX?IgM和TOX?IgG同为阳性者占2.65%（8/302），均高于对照组的2.03%（4/197）、7.61%（15/197）和0（0/197）（[χ2]值分别为6.07、11.67、3.76，P均< 0.05）。调查显示弓形虫感染孕妇中饲养宠物、菜板生熟不分、喜吃火锅或烧烤、吃生肉习惯、经常在外就餐等比例均明显高于未感染弓形虫的孕妇（[χ2]值分别为22.57、3.96、5.87、7.40、4.86，P均< 0.05），提示上述不良生活或卫生习惯可能是孕妇感染弓形虫的重要危险因素。结论 弓形虫感染可导致不良妊娠的发生。避免与宠物密切接触、不吃未煮熟的肉类以及加强个人卫生防护等是避免育龄妇女发生不良妊娠结局的有效途径。

关键词: 弓形虫；感染；不良妊娠；危险因素；霸州地区；河北省