Abstract:

Objective To understand the current status of Toxoplasma gondii （TOX） infection among pregnant women and to explore the risk factors in some areas of Lhasa City， Tibet. Methods From 2015 to 2016， 3 districts （counties） of Lhasa City were chosen as the investigation sites， and 200 pregnant women in each district （county） were selected as the investigation objectives. Meanwhile， 450 pregnant women from Xuzhou， Yangzhou， Wuxi cities in Jiangsu Province were chosen as the control. Then the blood samples of the pregnant women both in Lhasa and Jiangsu were detected by ELISA for TOX antibodies IgG， IgM， and the detection results were analyzed and compared. In addition， the individual information of the pregnant women in Lhasa City was surveyed by questionnaires， and the related risk factors of TOX infection were analyzed. Results Among 600 pregnant women investigated in Lhasa City， there were 99 pregnant women with positive TOX antibodies， and the positive rate was 16.50%， which was significantly higher than that （5.11%） of the pregnant women in Jiangsu Province （P < 0.05）. There was no statistically significant difference among the 3 districts （counties） of Lhasa City in the positive rates of pregnant women （P > 0.05）. The positive rates of the women who preferred raw meat or had the intimate contact with animal were high. Conclusions Compared with Jiangsu Province， the infection rate of TOX among pregnant women in Lhasa City is high. Therefore， the comprehensive measures including health education， early examination and treatment should be taken actively， so as to prevent and control TOX infection in this area.

Key words: Toxoplasma gondii （TOX）； Infection； Pregnant woman； Lhasa City

摘要： 目的 调查西藏拉萨地区孕妇弓形虫感染情况，并探讨相关危险因素。方法 2015-2016年，以拉萨市3个区（县）为调查地区，各地区选择200名孕妇为调查对象；另在江苏徐州、扬州、无锡3市选取450名孕妇为对照。采用酶联免疫吸附试验检测孕妇抗弓形虫抗体IgG、IgM水平，对检测结果进行分析。收集拉萨地区孕妇个案调查表信息，对弓形虫感染相关危险因素进行分析。结果 拉萨地区600名被调查孕妇中，99例抗弓形虫抗体阳性，抗体阳性率16.50%，与江苏省孕妇抗体总阳性率（5.11%）差异有统计学意义（P < 0.05）。拉萨3区（县）孕妇抗弓形虫抗体阳性率差异无统计学意义（P > 0.05）。喜食生肉者、有动物密切接触史者感染率高。结论 与江苏省相比，拉萨地区孕妇弓形虫感染率较高。应积极采取健康教育、早期检查及治疗等综合措施，以预防控制该地区孕妇弓形虫感染，提高优生优育水平。

关键词: 弓形虫；感染；孕妇；拉萨市