Chinese Journal of Schistosomiasis Control ›› 2023, Vol. 35 ›› Issue (2): 184-.

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Role of type 2 innate lymphoid cells in helminth infections: a review

YANG Yuxuan1, 2, WANG Zhixin1, 2, WU Binjie2, CHENG Shilei2, FAN Haining1, 2*   

  1. 1 Department of Hepatopancreatobiliary Surgery, The Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, China; 2 Qinghai Provincial Key Laboratory for Echinococcosis Research, Xining, Qinghai 810001, China
  • Online:2023-04-15 Published:2023-05-19


杨玉轩1, 2,王志鑫1, 2,吴彬杰2,程时磊2,樊海宁1, 2*   

  1. 1 青海大学附属医院肝胆胰外科(青海 西宁 810001);2 青海省包虫病研究重点实验室(青海 西宁 810001)
  • 作者简介:杨玉轩,男,博士研究生。研究方向:棘球蚴病基础与临床研究
  • 基金资助:

Abstract: Helminth infections may trigger host innate and adaptive immune responses. Group 2 innate lymphoid cells (ILC2) are an important factor involved in type 2 immune responses, and produce a large number of T helper 2 cell (Th2) cytokines following stimulation by interleukin (IL)⁃25, IL⁃33 and thymic stromal lymphopoietin (TSLP), which play a critical role in parasite clearance and tissue repair. Following helminth infections, autocrine factors, mast cells, enteric nervous system and Th2 cells have been recently found to be involved in regulation of ILC2. Unraveling the role of ILC2 in immune response against helminth infections is of great value for basic research and drug development. This review summarizes the research progress on ILC2 and its role in helminth infections.

Key words: Helminth, Group 2 innate lymphoid cell, Immune regulation

摘要: 蠕虫感染会诱发宿主产生固有及特异性免疫应答。2型固有淋巴细胞(group 2 innate lymphoid cells,ILC2)是2型免疫反应的重要参与者,在白细胞介素25(interleukin 25,IL⁃25)、IL⁃33和胸腺基质淋巴细胞生成素(thymic stromal lymphopoietin,TSLP)刺激下而产生大量辅助型T细胞2(T helper 2 cell, Th2)型细胞因子,从而在清除寄生虫及组织修复中发挥重要作用。近年来研究发现,蠕虫感染后,ILC2自分泌因子、肥大细胞、肠道神经系统、Th2细胞等均参与ILC2调控。探索ILC2在抗蠕虫免疫中发挥的作用极具基础研究与临床药物开发价值。本文就ILC2及其在蠕虫感染中的作用进行综述。

关键词: 蠕虫, 2型固有淋巴细胞, 免疫调控

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