Chinese Journal of Schistosomiasis Control ›› 2022, Vol. 34 ›› Issue (6): 598-.

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Epidemiological characteristics and influencing factors of Blastocystis hominis infection among children with diarrhea under five years of age in Guangzhou City

XU Wei⁃rong1△, WANG Guo⁃shu1△, LI Qin2, ZHENG Jin⁃xin2, GUO Zhao⁃yu2, CHEN Jia⁃xu2, CHEN Mu⁃xin2, TIAN Li⁃guang2*   

  1. 1 Institute of Disease Control and Prevention of China Railway Qinghai⁃Tibet Group Co., Ltd., Xining, Qinghai 810007, China; 2 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, School of Global Health, National Center for International Research on Tropical Diseases and Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2023-01-09 Published:2023-01-12

广州市5岁以下腹泻儿童人芽囊原虫感染流行病学特征及影响因素

徐维荣1△,王国淑1△,李琴2,郑金鑫2,郭照宇2,陈家旭2,陈木新2,田利光2*   

  1. 1 中国铁路青藏集团有限公司疾病预防控制所(青海 西宁 810007);2 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、WHO热带病合作中心、国家级热带病国际联合研究中心、上海交通大学医学院⁃国家热带病研究中心全球健康学院(上海 200025)
  • 作者简介:徐维荣,男,本科,主管检验师。研究方向:微生物检验及传染病预防和控制 王国淑,女,本科,初级检验师。研究方向:微生物检验及传染病预防和控制
  • 基金资助:
    上海市促进市级医院临床技能与临床创新能力三年行动计划(SHDC2022CRS039);上海市2021年“科学创新行动计划”医学创新研究专项(21Y11922500);上海中医药大学附属龙华医院人才基金(LH001.007);国家科技重大专项(2018ZX10101002);WHO示范项目 (UNOPS/AND/G/2016/01)

Abstract: Objective To investigate the prevalence and influencing factors of Blastocystis hominis infection among children with diarrhea under five years of age in Guangzhou City. Methods Children with diarrhea under 5 years of age admitted to Guangzhou Children’s hospital, Guangzhou Maternity and Child Healthcare Hospital and Guangzhou Women and Children’s Medical Center during the period between January 1 and December 31, 2020, were enrolled. Participants’ demographics, living environments and health status were collected using questionnaire surveys. Stool samples were collected from participants and nucleic acid was extracted. B. hominis infection was identified using PCR assay and sequence alignment, and the factors affecting B. hominis infection among children with diarrhea under 5 years of age were identified using univariate analysis and multivariate logistic regression analysis. Results A total of 684 children with diarrhea under 5 years of age were enrolled, including 468 male children and 216 female children, with a mean age of (1.79 ± 1.12) years. The overall prevalence of B. hominis infection was 4.97% [34/684, 95% confidential interval (CI): (3.59%, 6.86%)] among participants, and there was no significant difference in the prevalence of B. hominis infection between children with chronic [7.52% (20/266), 95% CI: (4.92%, 11.33%)] and acute diarrhea [3.35% (14/418), 95% CI: (2.01%, 5.54%)] ([χ2] = 5.983, P = 0.014). Multivariate logistic regression analysis identified keeping pet [odds ratio (OR) = 6.298, 95% CI: (2.711, 14.633)], drinking non⁃tap water [OR = 4.522, 95% CI: (1.769, 11.561)], lactose intolerance [OR = 4.221, 95% CI: (1.043, 17.087)], antibiotic use [OR = 0.125, 95% CI: (0.017, 0.944)] and chronic diarrhea [OR = 2.172, 95% CI: (1.018, 4.637)] as factors affecting B. hominis infection among children with diarrhea under 5 years of age in Guangzhou City. Conclusions B. hominis infections is detected in children with diarrhea under five years of age in Guangzhou City. Improving home environments and pet⁃keeping hygiene is recommended to reduce the likelihood of B. hominis infection among children.

Key words: Blastocystis hominis, Epidemiological characteristic, Influencing factor, Diarrhea, Children, Guangzhou City

摘要: 目的 了解广州市5岁以下腹泻儿童人芽囊原虫感染率及其影响因素。方法 以2020年1月1日至12月31日广州市儿童医院、广州市妇婴医院和广州市妇女儿童医疗中心收治的5岁以下腹泻患儿作为调查对象,通过问卷调查了解患儿基本情况、生活环境、健康状况等信息。采集腹泻患儿粪便样本,提取核酸,通过PCR检测、序列对比确定是否感染人芽囊原虫。采用单因素分析和多因素logistic回归分析对5岁以下腹泻儿童感染人芽囊原虫的影响因素进行分析。结果 共招募5岁以下腹泻儿童684例,其中男、女童分别为468例和216例,平均年龄为(1.79 ± 1.12)岁。腹泻儿童人芽囊原虫感染率为4.97% [34/684,95%置信区间(confidential interval, CI):(3.59%,6.86%)];慢性腹泻儿童感染率[7.52%(20/266),95% CI:(4.92%,11.33%)] 高于急性腹泻儿童 [3.35%(14/418),95% CI:(2.01%,5.54%)],差异有统计学意义([χ2] = 5.983,P = 0.014)。多因素logistic回归分析显示,饲养宠物 [比值比(OR)= 6.298,95% CI:(2.711,14.633)]、饮用非自来水[OR = 4.522, 95% CI:(1.769,11.561)]、乳糖不耐受 [OR = 4.221,95% CI:(1.043,17.087)]、使用抗生素 [OR = 0.125,95% CI:(0.017,0.944)] 和慢性腹泻 [OR = 2.172,95% CI:(1.018,4.637)] 是广州市5岁以下腹泻儿童人芽囊原虫感染的影响因素。结论  广州市5岁以下腹泻儿童中存在人芽囊原虫感染,建议改善家庭环境及宠物卫生状况,以降低儿童感染人芽囊原虫等病原体的机会。

关键词: 人芽囊原虫, 流行病学特征, 影响因素, 腹泻, 儿童, 广州市

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