Abstract: Objective To observe the toxity of niclosamide on the growth of silkworms. Methods Mulberry leaves were soaked in the different concentrations of solution of 50% ethanol salt powder of niclosamide for 10 s or 3 min，and then the leaves were fed to silkworms. The death rates of silkworms and the weight of cocoons were observed. Normal feeding control groups were established. Results The death rates were 22.5%-85.0% and 56.0%-100% in the 10?s?soaked groups and 3?min groups，respec? tively，which were significantly higher than those in the control groups. Conclusion The 50% ethanol salt powder of niclosamide has a toxity for silkworm. Therefore，we should properly handle the relationship between the Oncomelania snail control and silk? worm breeding.

Key words: 50% ethanol salt powder of niclosamide；Silkworm；Toxicity

摘要：

目的 观察50%氯硝柳胺乙醇胺盐粉剂 （WPN） 对家蚕的毒性。方法 将桑叶在1、 2、 4、 6、 8 g/L WPN中浸泡10 s 和3 min， 然后喂养家蚕， 观察家蚕死亡情况。并设清水对照组。结果 将桑叶在WPN中浸泡10 s后喂养家蚕21 d， 家蚕死亡率为22.5%~85.0%， 高于对照组的14.0%； 浸泡3 min后喂养家蚕24 d， 家蚕死亡率为56.0%~100%， 高于对照组的 8.5%。结论 WPN对家蚕有毒性， 须妥善处理灭螺与家蚕养殖的关系。

关键词: 50%氯硝柳胺乙醇胺盐粉剂； 家蚕； 毒性