Chinese Journal of Schistosomiasis Control ›› 2024, Vol. 36 ›› Issue (1): 98-104.DOI: 10.16250/j.32.1374.2023157

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Progress of researches on the antiparasitic activity of antimicrobial peptide LL⁃37

LOU Junchao1, 2, HE Xiaoqin1, 2*   

  1. 1 School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; 2 National Health Commission Key Laboratory of Parasitic Disease Prevention and Control Technology, Jiangsu Provincial Key Laboratory of Parasites and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu 214064, China
  • Online:2024-02-15 Published:2024-04-03



  1. 1 南京医科大学公共卫生学院(江苏 南京 211166);2 国家卫生健康委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫与媒介控制技术重点实验室、江苏省血吸虫病防治研究所(江苏 无锡 214064)
  • 作者简介:楼俊超,男,硕士研究生。研究方向:传染病防控策略与技术
  • 基金资助:

Abstract: Parasitic diseases caused by protozoan and helminth infections are still widespread across the world, notably in tropical and subtropical areas, which threaten the children and adult health. Long⁃term use of anti⁃parasitic drugs may result in reduced drug susceptibility and even drug resistance. Antimicrobial peptides have been demonstrated to inhibit parasite growth and development, which has potential antiparasitic values. LL⁃37, the only human antimicrobial peptide in the cathelicidin family, has been widely investigated. This paper reviews the progress of researches on the antiparasitic activity of LL⁃37, and discusses the prospects of LL⁃37 in the research of parasites.

Key words: Parasite, Human antimicrobial peptide, LL?37, Mechanism of action

摘要: 由原虫、蠕虫感染导致的寄生虫病在全球范围内广泛流行,尤其是在热带和亚热带地区,对儿童和成人生命健康均造成威胁。抗寄生虫药的长期使用导致寄生虫对药物敏感性下降甚至出现耐药性。研究表明抗菌肽可抑制寄生虫生长发育,具有潜在抗寄生虫价值,其中LL⁃37作为组织蛋白酶抑制素(cathelicidin)家族中唯一的人源抗菌肽被广泛研究。本文综述了LL⁃37抗寄生虫作用的研究进展,并对其作为抗寄生虫药物的候选资源的应用前景进行了探讨。  

关键词: 寄生虫, 人源抗菌肽, LL?37, 作用机制

CLC Number: