关键词: 华支睾吸虫病, 医防融合模式, 防治, 效果评价, 新会区

Abstract: Objective　To evaluate the effectiveness of a novel medical care and prevention integration mode for clonorchiasis control in Xinhui District, Jiangmen City, Guangdong Province, so as to provide insights into optimization of clonorchiasis control strategies in hyper⁃endemic areas.  Methods　A novel medical care and prevention integration mode was developed for clonorchiasis control in Xinhui District from 2019 to 2023 through a package of integrated interventions, including clonorchiasis clinics building, deworming, health education, improvements in water supply and sanitation facilities, and capacity building for professional personnels, and the proportion of clonorchiasis clinics building, coverage of deworming and health education, proportions of access to safe water and sanitary toilets, rate of qualified inspectors and percentage of trained professional personnels were collected in Xinghui District. Clonorchis sinensis human infections were detected using stratified cluster random sampling in Xinhui District in 2018 and 2023, and the awareness of clonorchiasis control knowledge was investigated among residents using questionnaire surveys. Results　Clonorchiasis clinics were built in all 15 healthcare facilities in Xinhui District in 2023, with the proportion of clinics building from 13.33% (2/15) in 2019 to 100.00% (15/15) in 2023, and a total of 1 575 clonorchiasis patients were treated, with a treatment coverage rate of 78.75% (1 575/2 000). Deworming was performed among high⁃risk residents consuming raw freshwater fish in Xinhui District in 2020, with a coverage rate of 75.00% (13 111/17 481), and the coverage rates of access to safe water and sanitary toilets were both 100.00% in the district. The rates of qualified inspectors were all 100.00% (15/15) in all healthcare facilities, and the rate of trained professional personnels increased from 52.94% (90/170) in 2019 to 98.05% (201/205) in 2023. The prevalence of C. sinensis human infections reduced from 34.18% (499/1 460) in 2018 to 10.20% (102/1 000) in 2023 ([χ2] = 172.10, P < 0.05), with a reduction from 44.68% (344/770) and 22.46% (155/690) in 2018 to 12.97% (62/478) and 7.66% (40/522) in 2023 among men ([χ2] = 135.06, P < 0.05) and women ([χ2] = 48.22, P < 0.05), respectively. In addition, the coverage rates of health education and awareness of clonorchiasis control knowledge increased from 50.00% (112/224) and 70.30% (142/202) to 98.21% (220/224) and 98.08% (204/208), respectively.  Conclusion　The novel medical care and prevention integration mode achieves remarkable effectiveness for clonorchiasis control in Xinhui District, which deserves wide applications in endemic areas.

Key words: Clonorchiasis, Medical care and prevention integration mode, Prevention and control, Effectiveness evaluation, Xinhui District