关键词: 狒狒巴拉姆希阿米巴脑炎, 脑脊液, 宏基因组二代测序, 儿童

Abstract: Balamuthia mandrillaris amebic encephalitis is a rare but highly fatal parasitic disease in the central nervous system caused by amebae infections. This disease is characterized by complex, diverse and non⁃specific clinical manifestations and high difficulty in diagnosis, resulting in a high likelihood of missing diagnosis and misdiagnosis. This article presents the diagnosis and treatment of a child with definitive diagnosis B. mandrillaris amebic encephalitis as revealed by metagenomic next⁃generation sequencing of cerebrospinal fluids, so as to provide insights into clinical diagnosis and treatment of B. mandrillaris amebic encephalitis.

Key words: Balamuthia mandrillaris amebic encephalitis, Cerebrospinal fluid, Metagenomic next?generation sequencing, Children