关键词: 蜱传脑炎病毒, 蜱传脑炎, 血清学检测, 核酸检测

Abstract: Tick⁃borne encephalitis is a central nervous system disease caused by infections with tick⁃borne pathogens, which is characterized by severe clinical symptoms, multiple sequelae, and a high fatality rate. Currently, there is no cure for tick⁃borne encephalitis. Tick⁃borne encephalitis virus (TBEV) is the most common pathogen of tick⁃borne encephalitis. Therefore, rapid and accurate detection of TBEV contributes to reducing the mortality of tick⁃borne encephalitis, improving patients' prognosis, and reducing the risk of TBEV transmission. The currently available serological tests for detection of TBEV infections mainly include neutralization test, enzyme⁃linked immunosorbent assay (ELISA), immunofluorescence assay, and nucleic acid tests mainly include polymerase chain reaction (PCR), loop⁃mediated isothermal amplification (LAMP), reverse transcription polymerase spiral reaction, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR⁃associated proteins (Cas)⁃based assays. This review summarizes the progress of researches on serological and nucleic acid tests for detection of TBEV infections, so as to provide insights into prevention and control of tick⁃borne encephalitis.

Key words: Tick?borne encephalitis virus, Tick?borne encephalitis, Serological test, Nucleic acid test