关键词: 包虫病；HLA?DRB1；易感性；抗性基因；关联研究；青藏高原

Abstract: Objective To determine the susceptibility genes and resistance genes in HLA?DRB1 alleles in Tibetan patients with cystic and alveolar hydatid diseases， so as to provide the references for the research of the genetic characteristics and infection mechanism of Tibetan hydatid diseases. Methods The case control method was applied. The Tibetan patients with cystic and alveolar hydatid diseases （63 and 73 cases respectively） in Yushu and Guoluo Tibetan Autonomous Prefecture， and unrelated healthy people （60 cases） in this area were selected as the study subjects. The polymerase chain reaction?sequence based typing （PCR?SBT） technique was applied for genotyping of HLA?DRB1， and the comparison of the gene frequency. Results The frequency of HLA?DRB1*04 in the alveolar/cystic echinococcosis group was lower than that in the control group （[χ2]= 4.71， 4.31， both P < 0.05）. Conclusion HLA?DRB1*04 genotypes may be associated with the resistance of cystic and alveolar echinococcosis and its resistance genes.

Key words: Echinococcosis； HLA?DRB1； Susceptibility； Resistance gene； Association study； Tibetan Plateau