关键词: 吡喹酮；日本血吸虫；肉芽肿；肝纤维化

Abstract:

  Objective  To explore the effect of praziquantel on schistosomal ovum granuloma in
the lung of mice. Methods   Forty-eight mice were divided int0 4 groups. Group A: first, the mice
were injected with schistosomal ova hypodermicly in abdomen and 10 days later, injected with schis-
tosomal ova intravenously in the cauda; Group B: in addition to the injection of schistosomal ova as
the same of Group A, the mice were administered with praziquantel [300 mg/(kg . d)] for 3 days
from the last day of the intravenous injection of the ova; Group C: in addition to the injection of
schistosomal ova as the same of Group A, the mice were administered with praziquantel (75 mg/
kg, B.i. d. ) for 5 days weekly until the mice were sacrificed; Group D:  the same as Group C but
praziquantel was given to the mice from the 29th after the intravenous injection of the ova. Three
mice of each group were sacrificed on the 7th, 14th, 28th, 56th day after the intravenous injection
of the ova and the lung tissues were fixed with formalin and the slices were HE stained. Fifteen-
thirty pieces of schistosomal ovum granuloma were examined and their areas were measured and the
mean areas of each group were calculated and compared. Results  On the 7th, 14th and 28th days
after the intravenous injection of the ova, the mean area of schistosomal ovum granuloma in Group
C was significantly less than that in Group A, and there was a significant difference between the
two groups, P <0. 05; and the area of schistosomal ovum granuloma in Group B was less than that
in Group A, but there was no significant difference between the two groups, P>0. 05.  On the 56th
day, the mean areas of schistosomal ovum granuloma in Group B, C, D were significantly less than
that in Group A, all P<0. 05.  Conclusionma.

Key words: Praziquantel, Schistosoma japonicum, Ovum granuloma, Hepatic fibrosis