关键词: 青蒿琥酯；日本血吸虫；敏感性

Abstract:

Objective To observe in vivo the susceptibility of different developed stages of schistosomulum and adult worm of Schistosoma japonicum to artesunate. Methods Mice infected with cercariae of Schistosoma japonicum were orally administered with artesunate in a single dose of 500 mg/kg at 2 h, 1, 3, 7, 12, 149 16, 25, 35 d and 42 d following the infection respectively. The mice were sacrificed and perfused by the portal perfusion method for the recovery of worms four weeks after the last administration. The worm reduction rates were calculated. Results The worm reduction rates of l, 3, 7, 12, 14, 16, 25, 35 d and 42 d old schistosomulum or adult worm groups were 16. 9%, 18. 0% , 71. 3% , 50. 2%, 36. 9%, 31. 3% , 45. 3% , 58. 0% and .26. 4% , respectively. Especially, the stage of 7-35 d old Schistosoma groups were the most susceptive to artesunate. Conclusions Artesunate possesses vermicidal effect on different developed stages of Schistosoma japonicum. Moreover, there is a obvious effect on 7-35 d old worms.

Key words: Artesunate , Schistosoma japonnicum, Susceptibility