Chin J Schisto Control ›› 2007, Vol. 19 ›› Issue (3): 188-191.

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Acute toxicity of LDS, a molluscicide 

Yuan Yi', Xu Xing-jian, Wei Feng-hua, Li Gui-ling, Zhao Yun-bin, Liu Min   

  • Online:2013-01-15 Published:2013-01-21

灭螺药物氯代水杨胺急性毒性试验

元艺.|徐兴建||魏凤华1|李桂玲2|赵云斌2|刘敏2   

  1. 1湖北省疾病预防控制中心血吸虫病防治研究所(武汉430079);2华中科技大学同济医学院
  • 作者简介:元艺(1979-)|女|硕士研究生.研究方向:血吸虫病及钉螺生物学

Abstract:

 Objective  To investigate the acute toxicity of LDS, a molluscicide. Methods  Ac-
cording to "the method of toxicity test for agriculture register" GB15670- 1995, an acute toxicity
test was carried out via mouth, skin and inbreathe with Wistar rat. Meanwhile, the eye and skin
stimulating test with rabbit as well as skin stimulating test with guinea pig were also conducted.
Results   Based on the classification of appraising criterion on acute toxicity test via mouth, skin and
inbreathe with Wistar rat, LDS belonged to a feebleness toxicity degree. Based on intension classifi-
cation criterion of acute skin stimulation, LDS was of no acute skin stimulation to the rabbit. Based
on intension classification criterion of acute eye stimulation, LDS was of no acute eye stimulation to
the rabbit. Based on intension classification criterion of impressible rate, LDS was feebly impress-
ible. Conclusion  LDS has a feeble toxicity degree to mammal.

Key words: Molluscicide, LDS, Acute toxicity test

摘要:

目的评价新型灭螺药氯代水杨胺(LDS)的急性毒性。方法按照《农业登记毒理学试验方法》GB 15670-1995,将LDS分别进行大鼠急性经口、经皮、吸入毒性试验,家兔急性眼刺激和皮肤刺激试验,以及豚鼠皮肤致敏试验。结果依据分级评价标准,LDS对大鼠急性经口、经皮、吸入毒性属微毒级,对家兔属无急性眼刺激性及无急性皮肤刺激性,对豚鼠皮肤致敏属弱致敏类。结论 LDS对哺乳动物的毒性属微毒级,是一种新型的安全灭螺药。

关键词:  灭螺药;氯代水杨胺;急性毒性试验

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