Abstract:

Praziquantel remains the drug of choice for schistosomiasis，but it has the low bioavailability and single dosage form. This paper reviews the properties of praziquantel in vivo and in vitro，the pathogenic characteristics of schistosomiasis，and the progress of research on the formation of praziquantel，so as to enhance the efficiency of praziquantel against schistosomiasis and provide consults for relevant drug researches.

Key words: Schistosomiasis； Praziquantel； Dosage form

摘要：

吡喹酮是临床有效治疗血吸虫病的首选药物， 然而其生物利用度低、 剂型单一、 对童虫作用不明显等缺点， 限制了其发挥最大效用。本文针对吡喹酮性质及药代动力学特点， 并结合现有吡喹酮新型制剂的研究进展做一综述， 为充分发挥吡喹酮的抗血吸虫作用以及吡喹酮新制剂的研究开发提供参考及借鉴。

关键词: 血吸虫病； 吡喹酮； 剂型