Abstract:

Objective  To explore the relationship between CD34 expression or microvessel den-
sity and hepatic fibrosis degree in advanced schistosomiasis patients. Methods  Thirty-five ad-
vanced schistosomiasis patients and 5 control patients were included in this study. CD34 expression
in liver tissue was measured with immunohistochemistry while microvessel density (MVD) of liver
tissue was evaluated under a light microscope. Results  CD34 expression and MVD value were sig-
nificantly correlated with hepatic fibrosis degree in liver tissue from the advanced schistosomiasis pa-
tients. Conclusions  CD34 expression and MVD value are two histological parameters representing
the liver sinusoid changes during fibrogenesis in advanced schistosonuasis patients.

Key words: Schistosomiasis japonica, Hepatic fibrosis, Liver sinusoid, CD34, Microvessel density

摘要：

目的探讨晚期日本血吸虫病患者肝组织CD34表达和微血管密度变化与肝纤维化程度的关系。方法应用免疫组化方法检测35例晚期血吸虫病患者及5例对照组患者肝组织标本的CD34表达，同时光镜下测定肝脏微血管密度。结果  晚期血吸虫病患者肝组织CD34表达及肝脏微血管密度随肝纤维化程度的进展而增加，CD34表达和肝脏微血管密度均与肝纤维化分期呈正相关。结论CD34表达和肝脏微血管密度可以作为临床观察晚期血吸虫病肝纤维化患者肝窦病变的重要组织学指标。

关键词: 日本血吸虫病；肝纤维化；肝窦；CD34;微血管密度