Abstract:

Objective To observe the compliance of film?coated praziquantel tablets in the schistosomiasis transmission controlled areas, so as to provide the evidence for the establishment of chemotherapy intervention measures in these areas. Methods In the areas of schistosomiasis transmission controlled in Sichuan Province, 234 people were selected as film?coated praziquantel group (FCPG), and 203 people were selected as praziquantel group (PG). A questionnaire survey was implemented and the compliance of chemotherapy of the 2 groups was compared. Results In PG, all the people indicated that the praziquantel tablets has bad smell, 98.0% of the people had side?effects, such as nausea, headache, 69.5% thought the medicine was harmful to health subjectively, and 99.5% thought that it was too much dose of tablets for taking one time. In FCPG, all the people indicated that the film?coated praziquantel tablets had no bad smell, 18.8% of the people had side?effects, and 74.4% would like to choose film?coated pra? ziquantel tablets. The rates of knowledge of praziquantel of PG and FCPG were 50.7% and 29.1%, respectively（χ2 =21.449, P = 0.01） . Conclusions The film?coated praziquantel tablets have no bad smell and lighter side?effects. The compliance of the film?coated praziquantel tablets is high in the areas of schistosomiasis transmission controlled, so the film?coated praziquantel tablets are worth to popularize and apply.

Key words: Schistosomiasis, Praziquantel, Chemotherapy, Compliance

摘要：

目的 观察吡喹酮薄膜衣片在血吸虫病传播控制地区人群中的化疗依从性， 为制定此类地区化疗干预措施提供科学依据。方法 在四川省血吸虫病传播控制地区， 分别选择吡喹酮薄膜衣片组234人， 吡喹酮素片组203人， 采用个人问卷调查方法进行调查， 比较2组人群的化疗依从性。结果 吡喹酮素片组调查对象100%表示药物具有刺激气味， 98.0% 服用后有恶心、 头痛等不良反应， 69.5%主观认为药物对身体有害， 99.5%表示服用的药量较多； 吡喹酮薄膜衣片组调查对象表示药物没有刺激气味， 18.8%服用后有不良反应， 74.4%愿意选用该剂型药物。吡喹酮素片组和薄膜衣片组对药物的了解率分别为50.7%和29.1%， 两组差异有统计意义 （χ2 =21.449， P＜0.01）。 结论 吡喹酮薄膜衣片刺激气味、 不良反应小， 在血吸虫病传播控制地区人群的化疗依从性高， 值得推广应用。

关键词: 血吸虫病；吡喹酮；化疗；依从性