Abstract: Objective　To evaluate the effectiveness of a novel medical care and prevention integration mode for clonorchiasis control in Xinhui District, Jiangmen City, Guangdong Province, so as to provide insights into optimization of clonorchiasis control strategies in hyper⁃endemic areas.  Methods　A novel medical care and prevention integration mode was developed for clonorchiasis control in Xinhui District from 2019 to 2023 through a package of integrated interventions, including clonorchiasis clinics building, deworming, health education, improvements in water supply and sanitation facilities, and capacity building for professional personnels, and the proportion of clonorchiasis clinics building, coverage of deworming and health education, proportions of access to safe water and sanitary toilets, rate of qualified inspectors and percentage of trained professional personnels were collected in Xinghui District. Clonorchis sinensis human infections were detected using stratified cluster random sampling in Xinhui District in 2018 and 2023, and the awareness of clonorchiasis control knowledge was investigated among residents using questionnaire surveys. Results　Clonorchiasis clinics were built in all 15 healthcare facilities in Xinhui District in 2023, with the proportion of clinics building from 13.33% (2/15) in 2019 to 100.00% (15/15) in 2023, and a total of 1 575 clonorchiasis patients were treated, with a treatment coverage rate of 78.75% (1 575/2 000). Deworming was performed among high⁃risk residents consuming raw freshwater fish in Xinhui District in 2020, with a coverage rate of 75.00% (13 111/17 481), and the coverage rates of access to safe water and sanitary toilets were both 100.00% in the district. The rates of qualified inspectors were all 100.00% (15/15) in all healthcare facilities, and the rate of trained professional personnels increased from 52.94% (90/170) in 2019 to 98.05% (201/205) in 2023. The prevalence of C. sinensis human infections reduced from 34.18% (499/1 460) in 2018 to 10.20% (102/1 000) in 2023 ([χ2] = 172.10, P < 0.05), with a reduction from 44.68% (344/770) and 22.46% (155/690) in 2018 to 12.97% (62/478) and 7.66% (40/522) in 2023 among men ([χ2] = 135.06, P < 0.05) and women ([χ2] = 48.22, P < 0.05), respectively. In addition, the coverage rates of health education and awareness of clonorchiasis control knowledge increased from 50.00% (112/224) and 70.30% (142/202) to 98.21% (220/224) and 98.08% (204/208), respectively.  Conclusion　The novel medical care and prevention integration mode achieves remarkable effectiveness for clonorchiasis control in Xinhui District, which deserves wide applications in endemic areas.

Key words: Clonorchiasis, Medical care and prevention integration mode, Prevention and control, Effectiveness evaluation, Xinhui District

摘要： 目的　评价华支睾吸虫病医防融合新型防治模式在广东省江门市新会区的实施效果，为优化高流行区华支睾吸虫病防控策略提供参考。方法　2019—2023年，新会区通过建设华支睾吸虫病防治门诊、开展驱虫治疗、健康教育、改水改厕及提升防治专业人员能力等综合措施的实施，构建华支睾吸虫病医防融合新型防治模式。收集新会区华支睾吸虫病防治门诊建设数量、门诊驱虫治疗人数、健康教育覆盖情况以及各级医疗卫生机构合格检验人员配备情况、防治专业人员培训情况等数据，了解华支睾吸虫病医防融合新型防治模式的实施情况。分别于2018、2023年采用分层整群随机抽样方法开展新会区人群华支睾吸虫感染调查，并通过问卷调查了解人群华支睾吸虫病防治知识知晓率，以评价该模式防治效果。结果　2023年新会区15家医疗卫生机构均建设了华支睾吸虫病防治门诊，门诊建设率由2019年的13.33%（2/15）提高至100.00%（15/15）；累计治疗患者1 575例，治疗率为78.75%（1 575/2 000）。2020年对食用“鱼生”的高危人群开展驱虫治疗，驱虫覆盖率达75.00%（13 111/17 481）。全区安全卫生水普及率与无害化卫生厕所普及率均达100.00%。各级医疗卫生机构合格检验人员配备率达100.00%（15/15），防治专业人员培训率从2019年的52.94%（90/170）提高至2023年的98.05%（201/205）。人群华支睾吸虫感染率由2018年的34.18%（499/1 460）下降至2023年的10.20%（102/1 000），差异有统计学意义（[χ2] = 172.10，P < 0.05）；其中，男、女性华支睾吸虫感染率分别从2018年的44.68%（344/770）、22.46%（155/690）下降至2023年的12.97%（62/478）、7.66%（40/522），差异均有统计学意义（[χ2]  = 135.06、48.22，P均< 0.05）。健康教育覆盖率、人群华支睾吸虫病防治知识知晓率分别从50.00%（112/224）、70.30%（142/202）提高至98.21%（220/224）、98.08%（204/208）。结论　华支睾吸虫病医防融合新型防治模式防治成效显著，在该病流行区具有推广应用价值。

关键词: 华支睾吸虫病, 医防融合模式, 防治, 效果评价, 新会区