Abstract: Objective　To systematically evaluate the economic burden of echinococcosis patients in western China using meta⁃analysis, so as to provide insights into formulation of effective echinococcosis control strategies and optimization of medical resource allocation. Methods　Articles pertaining to the economic burden of echinococcosis patients in western China were retrieved in  international and Chinese databases, including PubMed, Web of Science, CNKI, Wanfang Data, and VIP Chinese Science and Technology Periodicals Full⁃Text Database. Studies were screened according to inclusion and exclusion criteria, and the basic characteristics of included articles, characteristics of included studies, and echinococcosis patients' economic burden were extracted.  A meta⁃analysis was performed using the software R package. The pooled effect size and heterogeneity were examined using a random effects model, and subgroup analyses were conducted. Results　A total of 13 articles were enrolled, including 12 Chinese publications and one English publication, and all were retrospective studies. Included studies covered 4 western provinces (autonomous regions) of China, including Ningxia Hui Autonomous Region, Xinjiang Uygur Autonomous Region, Sichuan Province, and Qinghai Province, which involved 11 282 echinococcosis patients, and the study period spanned from 2006 to 2023. Meta⁃analysis showed that the pooled direct medical costs of echinococcosis patients were 24 730 [95% confidence interval (CI): (13 040, 36 430)] Yuan in endemic areas of western China, appearing a significant heterogeneity (I2 = 79.95%, P < 0.01). Subgroup analyses showed the pooled direct medical costs of 9 090 [95% CI: (-4 970, 23 150)] Yuan for echinococcosis patients in Ningxia Hui Autonomous Region and 18 140 [95% CI: (8 440, 27 840)] Yuan in Xinjiang Uygur Autonomous Region, and pooled direct medical costs of 9 470 [95% CI: (-1 850, 20 790)] Yuan for cystic echinococcosis patients prior to 2007 and 15 270 [95% CI: (560, 24 030)] Yuan after 2007, respectively. There were high heterogeneities in the pooled direct medical costs for echinococcosis patients in terms of date of publication (I2 = 82.05%, P < 0.001), treatment modality (I2 = 83.28%, P < 0.001) and type of echinococcosis (I2 = 72.63%, P < 0.001). In addition, the pooled indirect medical costs and direct non⁃medical costs were 5 670 Yuan and 4 000 Yuan for echinococcosis patients in western regions of China, respectively. Conclusions　Echinococcosis patients suffer from a high economic burden in endemic areas of western China, and there are disparities in the direct medical costs for echinococcosis patients depending on disease type, study areas and study period.

Key words: Echinococcosis, Economic burden, Meta?analysis, Western area, China

摘要： 目的　采用meta分析系统评估我国西部地区棘球蚴病患者经济负担，为制定有效防控策略和优化医疗资源配置提供依据。方法　在PubMed、Web of Science、中国知网、万方数据库和中文科技期刊数据库等中外数据库中检索我国西部流行区棘球蚴病患者经济负担相关文献，根据纳入与排除标准筛选文献，提取纳入文献基本信息、研究特征数据及患者经济负担数据等。使用R软件进行meta分析，采用随机效应模型评估合并效应量和异质性，并进行亚组分析。结果　共纳入13篇文献，其中中文文献12篇、英文文献1篇，均为回顾性研究。纳入文献研究范围涵盖我国宁夏回族自治区、新疆维吾尔自治区、四川省、青海省4个西部省份，涉及11 282名患者，研究时间跨度为2006—2023年。Meta分析结果显示，我国西部流行区棘球蚴病直接医疗成本的合并效应量为2.473万元［95%可信区间（confidence interval，CI）：（1.304，3.643）］，存在显著异质性（I2 = 79.95%，P < 0.01）。直接医疗成本亚组分析显示，宁夏回族自治区棘球蚴病直接医疗成本合并效应量为0.909万元［95% CI：（−0.497，2.315）］，新疆维吾尔自治区合并效应量为1.814万元［95% CI：（0.844，2.784）］；2007年前细粒棘球蚴病直接医疗成本合并效应量为0.947万元［95% CI：（−0.185，2.079）］，2007年后为1.527万元［95% CI：（0.056，2.403）］；发表时间（I2 = 82.05%，P < 0.001）、治疗方式（I2 = 83.28%，P < 0.001）、疾病类型亚组（I2 = 72.63%，P < 0.001）异质性较高。我国西部地区棘球蚴病间接医疗成本和直接非医疗成本的合并效应量分别为0.567万元和0.400万元。结论　我国西部流行区棘球蚴病患者承受经济负担较重，其中直接医疗成本因疾病类型、研究地区及研究期限等因素不同而异。

关键词: 棘球蚴病, 经济负担, meta分析, 西部地区, 中国