Abstract: Objective　To evaluate the effectiveness of the integrated soil⁃borne nematodiasis and clonorchiasis control programmesin Guizhou Province from 2019 to 2023, so as to provide insights into formulation of appropriate parasitic disease control strategies in the province.  Methods　From 2019 to 2023, Shiqian County in Tongren City and Zhenfeng County in Qianxi'nan Buyi and Miao Autonomous Prefecture were selected as pilot counties in Guizhou Province for soil⁃borne nematodiasis prevention and control programmes, and Rongjiang County in Qiandongnan Miao and Dong Autonomous Prefecture was selected as a pilot county for clonorchiasis control programmes. Integrated control measures were implemented in these 3 pilot counties, including surveys on human parasitic infections, deworming, health education and improved water and sanitation. At least 1 000 individuals were sampled from each of three pilot counties using a stratified multi⁃stage random sampling method from 2019 to 2023 for detection of soil⁃borne nematodes and Clonorchis sinensis human infections, and the awareness of soil⁃borne nematodiasis and clonorchiasis control knowledge was investigated among residents in pilot counties using questionnaire surveys. In addition, the implementation of deworming and coverage of sanitary toilets and safe drinking water were collected in three pilot counties. Results　   The prevalence of soil⁃borne nematode human infections reduced from 7.78% (79/1 016), 2.80% (28/1 001) and 14.40% (144/1 000) in 2019 to 1.18% (12/1 014), 1.38% (14/1 001) and 2.73% (28/1 024) in 2023 in Shiqian County, Zhenfeng County, and Rongjiang County, respectively ([χ2] = 51.51, 4.91 and 88.54, all P values < 0.05). No C. sinensis human infections were detected Shiqian County or Zhenfeng County from 2019 to 2023, and the prevalence of C. sinensis human infections reduced from 1.80% (18/1 000) in 2019 to 0.29% (3/1 024) in 2023 in Rongjiang County ([χ2] = 11.19, P < 0.05). Free deworming was provided to 574 cases with soil⁃borne nematode infections and 47 cases with C. sinensis infections detected in three pilot counties from 2019 to 2023. The coverage of health education was 100% in both Zhenfeng County and Shiqian County during the period from 2019 to 2023, and the awareness of soil⁃borne nematodiasis control knowledge increased from 93.60% (234/250) in Zhenfeng County and 70.97% (577/813) in Shiqian County in 2019 to 99.20% (248/250) and 98.40% (492/500) in 2023, respectively. The coverage of health education increased from 60.07% (161/268) in 2019 to 100% (250/250) in 2023 in Rongjiang County, and the awareness of clonorchiasis control knowledge increased from 80.67% (121/150) in 2019 to 99.20% (248/250) in 2023. The coverage of sanitary toilets increased from 48.89% (61 078/124 935), 34.20% (40 381/118 085) and 70.55% (60 604/85 920) in 2019 to 65.87% (77 649/117 878), 56.00% (63 252/112 948) and 89.15% (72 737/81 590) in 2023 in Shiqian County, Zhenfeng County and Rongjiang County, respectively, and the coverage of safe drinking water was all 100% in both Shiqian County and Rongjiang County during the 5⁃year study period, and increased from 85.33% (100 765/118 085) in 2019 to 100% (112 948/112 948) in 2023 in Zhenfeng County. Conclusions　There were remarkable reductions in the prevalence of soil⁃borne nematodes human infections in Shiqian County, Zhenfeng County, and Rongjiang County and in the prevalence of C. sinensis human infections in Rongjiang County, Guizhou Province following the 5⁃year integrated control programmes from 2019 to 2023. The widespread application of the health education⁃led and human parasitic diseases examination and treatment⁃based integrated soil⁃borne nematodiasis and clonorchiasis control programmes seems justified. 

Key words: Soil?borne nematodiasis, Clonorchiasis, Integrated control, Effectiveness evaluation, Guizhou Province

摘要： 目的　评价2019—2023年贵州省土源性线虫病和华支睾吸虫病综合防治措施实施效果，为该省制定适宜的寄生虫病防控策略提供科学依据。方法　2019—2023年，选择贵州省铜仁市石阡县、黔西南布依族苗族自治州贞丰县为土源性线虫病防治试点县，选择黔东南苗族侗族自治州榕江县为华支睾吸虫病防治试点县，开展人群寄生虫感染情况调查、药物驱虫、健康教育、改水改厕等综合防治措施。2019—2023年3个试点县均采用分层多阶段随机抽样方法选择调查对象，每个试点县均抽取不少于1 000人开展人群土源性线虫和华支睾吸虫感染调查。通过问卷调查了解试点县人群寄生虫病防治知识知晓情况。此外，收集3个试点县药物驱虫实施情况以及卫生厕所普及率、安全饮用水普及率等数据。结果　石阡县、贞丰县和榕江县人群土源性线虫感染率分别从2019年的7.78%（79/1 016）、2.80%（28/1 001）和14.40%（144/1 000）下降至2023年的1.18%（12/1 014）、1.38%（14/1 001）和2.73%（28/1 024），差异均有统计学意义（[χ2] = 51.51、4.91、88.54，P均< 0.05）。2019—2023年石阡县和贞丰县均未检出华支睾吸虫感染者；榕江县人群华支睾吸虫感染率从2019年的1.80%（18/1 000）下降至2023年的0.29%（3/1 024），差异有统计学意义（[χ2] = 11.19，P < 0.05）。对2019—2023年3个试点县查出的574例土源性线虫感染者和47例华支睾吸虫感染者均进行了免费驱虫治疗。贞丰县和石阡县自2019年起健康教育覆盖率均为100%，人群土源性线虫病防治知识知晓率分别由2019年的93.60%（234/250）和70.97%（577/813）上升至2023年的99.20%（248/250）和98.40%（492/500）。榕江县健康教育覆盖率从2019年的60.07%（161/268）上升至2023年的100%（250/250），人群华支睾吸虫病防治知识知晓率由2019年的80.67%（121/150）上升至2023年的99.20%（248/250）。2019—2023年石阡县、贞丰县和榕江县卫生厕所普及率均有所提高，分别从2019年的48.89%（61 078/124 935）、34.20%（40 381/118 085）和70.55%（60 604/85 920）上升至2023年的65.87%（77 649/117 878）、56.00%（63 252/112 948）和89.15%（72 737/81 590）；石阡县和榕江县安全饮用水普及率自2019年起均为100%，贞丰县从2019年的85.33%（100 765/118 085）上升至2023年的100%（112 948/112 948）。结论　经过5年综合防治，贵州省石阡县、贞丰县和榕江县人群土源性线虫感染率以及榕江县人群华支睾吸虫感染率均显著下降，以健康宣教为先导、人群查治病为主的综合防治模式值得推广应用。

关键词: 土源性线虫病, 华支睾吸虫病, 综合防治, 效果评价, 贵州省