Abstract: Hookworm infection remains a global health concern, which threatens human health. Hookworm infection is widely prevalent across the world, notably in tropical and subtropical areas. Recently, with the in?depth study of the immunity of parasitic infections, the “bidirectional effect” of host immune responses induced by helminth infections (including hookworm infections) has become increasingly prominent. On one hand, an immune response is induced in the host to kill the infected worms; on the other hand, the host produces a series of immunological changes that are conducive to the maintenance of parasite survival. The immune state of the host is regulated by various complicated mechanisms, and this may lead to the reduction in the incidence of allergic and autoimmune diseases or alleviation of the disease symptoms, which provide new insights into the management of these allergic and autoimmune diseases. The present article reviewed the advances of host immune responses induced by hookworm infection and its potential values in the treatment of allergic asthma, inflammatory bowel disease and rheumatoid arthritis.

Key words: Hookworm disease, Immune response, Therapeutic value, Allergic asthma, Inflammatory bowel disease, Rheumatoid arthritis

摘要： 钩虫病是影响人类健康的全球性公共卫生问题之一，尤其在热带及亚热带地区，人群钩虫感染较为普遍。近年来，随着寄生虫感染免疫学研究的不断深入，发现钩虫等蠕虫感染引起的宿主免疫应答作用的“双向性”日益凸显：一方面诱导宿主产生杀伤感染蠕虫的免疫应答；另一方面也会引起宿主产生一系列有利于维持寄生虫寄生的免疫学改变，即通过多种复杂机制调控宿主免疫状态，导致感染宿主过敏性及自身免疫性疾病的发病减少或症状减轻，这为此类疾病的干预提供了新的思路。本文对钩虫感染后宿主免疫应答，及其对过敏性哮喘、炎症性肠病及类风湿性关节炎等疾病的潜在治疗价值研究进展进行综述。

关键词: 钩虫病, 免疫应答, 治疗价值, 过敏性哮喘, 炎症性肠病, 类风湿性关节炎