Abstract: Objective To investigate the prevalence and risk factors of Toxoplasma gondii infection among pregnant women in Wuxi City of Jiangsu Province， so as to provide the evidence for developing the preventive and control interventions of T. gondii infection. Methods The anti?Toxoplasma IgM and IgG antibodies were detected by using ELISA in the sera sampled from 3 014 pregnant women from 2011 to 2014， and the pregnant outcomes were followed up. The risk factors of T. gondii infection were identified with questionnaires. Results Among the 3 014 pregnant women， 215 cases were found positive to anti?Toxoplasma antibody （7.13%）， including 49 cases positive to IgM antibody （49/215， 22.79%）， and 166 cases positive to IgG antibody （166/215， 77.21%）. The follow?up revealed that 46 T. gondii?infected pregnant women developed adverse pregnant outcomes （46/215， 21.40%）， including 35 cases positive to IgM antibody （35/46， 76.09%） and 11 cases positive to IgG antibody （11/46， 23.91%）. Of the 275 pregnant women without T. gondii infection， 7 cases were found to have adverse pregnant outcomes （2.55%）， which was significantly lower than that in T. gondii?infected pregnant women （P < 0.01）. The univariate analysis showed that the close contact with animals， liking eating raw meat， liking eating hot pot or barbecue， and tasting raw meat stuffing were important risk factors of T. gondii infection in pregnant women， compared with the uninfected group (all P values < 0.01）. Conclusions T. gondii infection may lead to adverse pregnant outcomes among pregnant women. Reduction of close contact with animals， development of good diet and hygiene habits and monitoring of T. gondii infection during pregnancy are effective approaches to avoid the development of adverse pregnant outcomes.

Key words: Toxoplasma gondii infection； Pregnant woman； Sero?epidemiology； Risk factor； Pregnant outcome； Wuxi region

摘要： 目的 调查江苏省无锡市孕妇弓形虫感染情况及其危险因素，为制定预防控制孕妇弓形虫感染措施提供参考依据。 方法 2011-2014年采用酶联免疫吸附试验（ELISA）对3 014例孕妇进行抗弓形虫IgM和IgG抗体检测并追踪随访，观察其妊娠结局；采用问卷调查孕妇弓形虫感染的危险因素。 结果 3 014例被调查的孕妇中，弓形虫抗体检测阳性215例，抗体阳性率为7.13%，其中IgM抗体阳性49例（占22.79%），IgG抗体阳性166例（占77.21%）。随访结果表明，215例感染弓形虫的孕妇中46例出现不良妊娠结局（占21.40%），其中35例IgM抗体阳性（76.09%），11例IgG抗体阳性（23.91%）。275例未感染弓形虫孕妇中，7例出现不良妊娠结局（占2.55%）。弓形虫感染和未感染孕妇不良妊娠结局发生率差异有统计学意义（P < 0.01）。单因素分析显示，与动物密切接触、喜吃生肉、喜吃火锅或烧烤、品尝生肉馅等是孕妇感染弓形虫的重要危险因素（与未感染组比较，P < 0.01）。 结论 孕妇弓形虫感染可导致不良妊娠结局的发生，减少动物密切接触、养成良好的饮食卫生习惯以及做好孕期弓形虫感染监测工作等是避免不良妊娠结局的有效途径。

关键词: 弓形虫感染；孕妇；血清流行病学；危险因素；妊娠结局；无锡地区