Abstract:

［Abstract］ Objective To explore the risk factors of portal vein thrombosis （PVT） after splenectomy and esophagogastric devascularization for advanced schistosomiasis portal hypertension. Methods The clinical data were collected retrospectively from 211 advanced schistosomiasis portal hypertension patients after splenectomy and esophagogastric devascularization from August， 2004 to March 2014， and all the data were analyzed statistically for the risk factors of PVT after the surgery by single factor analysis and Logistic regression analysis. Results Totally 59 patients were found with PVT and the incidence was 27.96% （59/211）. The single factor analysis showed that 8 factors were related to PVT after surgery， including the history of upper gastrointestinal hemorrhage， the diameter of portal vein， the diameter of splenic vein， esophageal varices， ascites， portal hypertension gastropathy， gastric varices， and blood ammonia level. The Logistic regression analysis showed that the independent risk factors of PVT were the diameter of portal vein （OR = 1.763，P = 0.000）and portal hypertension gastropathy（OR = 1.089，P = 0.037）. Conclusions The incidence of PVT after surgery for advanced schistosomiasis is high， and the independent risk factors are the diameter of portal vein and portal hypertension gastropathy.

Key words: Advanced schistosomiasis, Portal hypertension, Portal vein thrombosis, Risk factor, Logistic regression

摘要：

［摘要］　目的 探讨晚期血吸虫病门脉高压症脾切除贲门周围血管离断术后门静脉血栓（PVT）形成的危险因素。方法 收集2004年8月至2014年3 月期间本院外科收治的211例晚期血吸虫病门静脉高压症患者的临床资料，对可能影响术后PVT形成的因素进行单因素分析和Logistic回归分析。结果 211例患者中，59例术后PVT形成，发生率为27.96%（59/211）。单因素分析显示术前上消化道出血史、门静脉直径、脾静脉直径、食管静脉曲张程度、腹水、门脉高压性胃病、胃底静脉曲张、血氨水平是患者术后PVT形成的影响因素。Logistic 回归分析显示门静脉直径（OR = 1.763，P = 0.000）和门脉高压性胃病（OR = 1.089，P = 0.037）是患者术后PVT形成的独立危险因素。结论 晚期血吸虫病门脉高压症术后PVT形成的发生率较高，门静脉直径和门脉高压性胃病是PVT形成的独立危险因素。

关键词: 晚期血吸虫病, 门脉高压症, 门静脉血栓形成, 危险因素, Logistic回归