Progress of researches on the involvement of indoleamine 2, 3-dioxygenase in regulation of parasite-host immune interactions

Chin J Schisto Control ›› 2021, Vol. 33 ›› Issue (2): 209-.

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Progress of researches on the involvement of indoleamine 2, 3-dioxygenase in regulation of parasite-host immune interactions

WANG Li-Jun1, MA Pei-Yu2, LIU Hui1, CAO Jian-Ping3, LI Hua-Mei3， ZHENG Ming-Hui1, 3*

1 Department of Parasitology, Zunyi Medical University, Guizhou Key Laboratory of Gene Detection and Treatment, Zunyi 563003, China; 2 Institute of Criminal Science and Technology, Jiaozuo Municipal Public Security Bureau, Henan Province, China; 3 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, China

Online:2021-04-30 Published:2021-04-30

吲哚胺2, 3-双加氧酶参与调控寄生虫与宿主免疫互作关系的研究进展

王莉君1，马培玉2，刘晖1，曹建平3，李华美3，郑明辉1, 3*

1 遵义医科大学寄生虫学教研室、贵州省基因检测与治疗特色重点实验室（遵义563003）；2 河南省焦作市公安局刑事科学技术研究所；3中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、世界卫生组织热带病合作中心、国家级热带病国际联合研究中心

作者简介:王莉君，女，硕士研究生。研究方向：寄生虫感染与免疫、重要寄生虫功能基因组学
基金资助:
国家自然科学基金（81760373、31960025）；贵州省科技厅科技基金（黔科合基础[2016]1168）；遵义医科大学博士启动基金项目（F?795）；卫生部寄生虫病原与媒介生物学重点实验室开放课题（WSBKFKT?201609）

Abstract

Abstract: Indoleamine 2, 3?dioxygenase (IDO) is an important immunoregulatory enzyme, which mediates immune effects by depleting tryptophan and producing multiple metabolites. Recently, the studies on the immune function of IDO have been mostly restricted in tumors and autoimmune diseases. Nevertheless, there are few studies pertaining to the role of IDO in parasitic diseases, notably in parasite?host immune interactions. This review mainly describes IDO?mediated immunoregulatory effects and its regulation of parasite?host interactions, so as to provide insights into the development of immune intervention schemes against parasitic diseases.

Key words: Parasite, Indoleamine 2, 3?dioxygenase, Immune interaction, Immune escape

摘要： 吲哚胺2, 3?双加氧酶（indoleamine 2, 3?dioxygenase, IDO）是一种重要的免疫调节酶，主要通过耗竭色氨酸（tryptophan, Trp）和产生多种代谢产物来调节免疫效应。近年来，对IDO免疫功能的研究大多局限在肿瘤、自身免疫性疾病等领域，而在寄生虫病中的研究相对较少，尤其是寄生虫与宿主免疫互作关系的研究。本文综述了IDO介导的免疫调节作用及其与寄生虫?宿主间关系的研究进展，旨在为抗寄生虫病免疫干预方案的研究提供思路。

关键词: 寄生虫, 吲哚胺2, 3?双加氧酶, 免疫互作, 免疫逃避

CLC Number:

WANG Li-Jun, MA Pei-Yu, LIU Hui, CAO Jian-Ping, LI Hua-Mei， ZHENG Ming-Hui. Progress of researches on the involvement of indoleamine 2, 3-dioxygenase in regulation of parasite-host immune interactions[J]. Chin J Schisto Control, 2021, 33(2): 209-.

王莉君，马培玉，刘晖，曹建平，李华美，郑明辉. 吲哚胺2, 3-双加氧酶参与调控寄生虫与宿主免疫互作关系的研究进展[J]. 中国血吸虫病防治杂志, 2021, 33(2): 209-.

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Progress of researches on the involvement of indoleamine 2, 3-dioxygenase in regulation of parasite-host immune interactions

吲哚胺2, 3-双加氧酶参与调控寄生虫与宿主免疫互作关系的研究进展

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