Chin J Schisto Control ›› 2020, Vol. 32 ›› Issue (2): 148-.

### Effect of schistosomiasis japonica on the development of gastric and colorectal cancer

WANG Zi-Jian1, YANG Jiang-Hua2*

1. 1 Graduate School of Wannan Medical College, Wuhu 241001, China； 2 Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu City, Anhui Province, China
• Online:2020-04-30 Published:2020-04-30

### 日本血吸虫病对胃癌和结直肠癌发生的影响

1. 1 皖南医学院研究生学院(芜湖 241001)；2 皖南医学院第一附属医院弋矶山医院
• 作者简介:王子健，男，硕士研究生。研究方向：传染病学
• 基金资助:
国家自然科学基金主任基金（81141083）；安徽省高校省级自然科学研究项目（KJ2014A271）

Abstract: Objective　To examine the effect of schistosomiasis on the development of gastric cancer and colorectal cancer. Methods　The clinical data of patients with gastric cancer and colorectal cancer with and without schistosomiasis japonica that were admitted to the Yijishan Hospital Affiliated to Wannan Medical College from January 2014 to December 2018 were collected. All cases were divided into schistosomal gastric cancer group and non?schistosomal gastric cancer group, schistosomal colorectal cancer group and non?schistosomal colorectal cancer group. The risk factors of gastric cancer and colorectal cancer were identified using univariate analysis and multivariate logistic regression analysis, and the effects of schistosomiasis on the development and progression of gastric cancer and colorectal cancer were evaluated. In addition, the survival of 32 patients with schistosomal colorectal cancer and 68 cases with non?schistosomal colorectal were estimated using telephone follow?up, and compared. Results　There were 113 patients with schistosomal gastric cancer and 3 741 cases with non?schistosomal gastric cancer enrolled in this study, and there were significant differences between them in terms of sex ratio, age and prevalence of Helicobacter pylori infection （all P values < 0.05）. Logistic regression analysis revealed that age, H. pylori infection, and schistosomiasis were independent risk factors for gastric cancer （all P values < 0.05）. There were 184 patients with schistosomal colorectal cancer and 2 205 cases with non?schistosomal colorectal cancer recruited in this study, and there were significant differences between them in terms of age, sex ratio, rate of history of alcohol consumption and rate of positive fecal occult blood test （all P values < 0.05）. The phenotypes of both schistosomal and non?schistosomal colorectal cancer were predominantly ulcerative; however, the proportion of patients with invasive and protruded colorectal cancer was significantly greater than that of patients with non?schistosomal colorectal cancer （P = 0.003）. Logistic regression analysis revealed that age （P = 0.003）, gender （P = 0.002）, phenotype （P = 0.005） and schistosomiasis （P = 0.029） were independent risk factors for colorectal cancer. The 5?year survival rate was significantly higher in patients with schistosomal colorectal cancer （68.90%） than in those with non?schistosomal colorectal cancer （46.40%）, and the dead patients with schistosomal colorectal cancer had a significantly greater mean age than those with non?schistosomal colorectal cancer [（66.33 ± 3.08） years vs. （56.29 ± 1.94）, P < 0.05]. Conclusions 　Schistosomiasis may alter the pathogenesis of colorectal cancer, resulting in the differences in the epidemiology, clinical characteristics and 5?year survival rate between patients with schistosomal and non?schistosomal colorectal cancer. Periodical gastrointestinal endoscopy and other examinations are recommended to exclude the likelihood of gastrointestinal cancers in men with anemia of unknown causes and at ages of 60 years living in schistosomiasis?endemic areas.

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