Abstract: Objective To explore the status of depression in patients with advanced schistosomiasis and its influencing fac? tors，so as to provide the evidence for improving psychological interventions. Methods A total of 206 patients with advanced schistosomiasis were investigated with the self?designed general information questionnaire，the Self?Rating Depression Scale，and WHOQOL?BREF Form. Results Among the 206 cases，the incidence of depression was 69.4%，and depression was negatively related to the quality of life（P = 0.000） . The multiple logistic regression analysis showed that the times of hospitalization（β= 0.442，P = 0.007）was a risk factor for depression，while the high education levels（β = -0.583，P = 0.011）and the history of por? tal hypertension operation（β= -0.917，P = 0.000）were the protective factors. Conclusion The incidence of depression in ad? vanced schistosomiasis patients is high，and it is influenced by various factors. Therefore，we should take corresponding interven? tions to reduce its occurrence.

Key words: Advanced schistosomiasis； Depression； Quality of life；Influencing factor

摘要： 目的 目的 探讨晚期血吸虫病 （晚血） 患者抑郁状况及其影响因素。方法 方法 采用描述性研究设计， 应用自编的一般资 料调查表、 抑郁自评量表、 世界卫生组织生存质量测定量表简表对206例患者进行调查。结果 结果 206例晚血患者抑郁发生 率为69.4%， 抑郁与生活质量各维度呈负相关 （P = 0.000）； 多因素Logistic回归分析显示住院次数 （β = 0.442， P = 0.007） 是 晚血患者出现抑郁情绪的危险因素， 而文化程度高 （β = - 0.583， P = 0.011）、 门静脉高压症手术史 （β = -0.917， P = 0.000） 是 患者出现抑郁情绪的保护因素。结论 结论 晚血患者抑郁发生率较高， 受多方面因素的影响； 应采取针对性干预措施以改善 晚血患者的心理状况， 降低其抑郁情绪的发生。

关键词: 晚期血吸虫病； 抑郁； 生活质量； 影响因素