Abstract: Objective To compare the anthelmintic effect of albendazole with that of triclabendazole against Fasciola giganti? ca. Methods Two patients infected with Fasciola gigantica were investigated，and one was administered with albendazole orally （200 mg，twice per day for 5 days）and another was administered with triclabendazole［10 mg/ （kg ? d）for 2 days］ . Their total fe? ces were collected daily during the period of whole therapy，and the eggs of the parasite were collected by using the nylon bag method，and incubated at 28 ℃. Results The parasite eggs were detected from the first patient’ s dejecta on the 1st，2nd and 5th day after the end of the treatment，and no miracidiums hatched out as well as no eggs developed during the period of 25 days of the incubation. Meanwhile，her body temperature fluctuated between 37.4 ℃ and 38.3 ℃，and she still complained bellyache. For the other invalid，the eggs were not detected on the 2nd and 5th day after the end of the treatment. However，the eggs before and dur? ing the treatment developed the miracidiums of Fasciola gigantica on the 13th day after the incubation，but the eggs collected from the 1st day after the termination of the therapy did not develop and no miracidiums hatched out. At the same time，the signs and symptoms of the patient vanished after the 4th day of the end of the therapy. Conclusions Albendazole has no obvious insecticid? al activity on adult Fasciola gigantica in the short term，but may affect the development of eggs. Triclabendazole has the anthelmin? tic effect on the adults as well as eggs of Fasciola gigantica. In addition，triclabendazole has the characteristics of well curative ef? fect， short course of treatment，and no obvious side effects.

Key words: Fasciola gigantica； Albendazole； Triclabendazole；Anthelmintic effect

摘要： 目的 目的 比较阿苯达唑和三氯苯哒唑对人体大片形吸虫的驱虫效果。方法 方法 第1例患者口服阿苯达唑200 mg， 1日 2次， 连服5 d， 另1例患者每日顿服三氯苯哒唑片剂10 mg/kg， 连服2 d。收集2例患者服药后第1、 2、 5天的全量粪便 （共3 份）， 以及第2例患者服药前和服药期间的全量粪便 （共7份）， 采用尼龙袋集卵法收集虫卵， 并置于28 ℃水浴箱中孵化。结 结 果 果 第1例患者口服阿苯达唑后的第1、 2、 5天粪便中均检出片形吸虫卵， 经28 ℃水浴箱孵化， 持续观察25 d， 未见毛蚴孵 出， 也未见虫卵发育的迹象， 同时患者体温波动在37.4 ~ 38.3 ℃之间， 仍感腹痛。另1例患者在服用三氯苯哒唑前和服药 期间以及结束后第1天的粪便中检出虫卵， 服药结束后的第2、 5天粪便中未检出虫卵。服药前及期间排出的虫卵经28 ℃ 水浴箱孵化至第13天孵化出毛蚴； 而服药结束后第1天的虫卵持续观察25 d未见毛蚴孵出， 也未见虫卵发育的迹象， 同时 患者在服药结束后第4天症状和体征完全消失。结论 结论 阿苯达唑对大片形吸虫成虫短期内无明显的杀虫作用， 但可明显 影响虫卵的发育， 致使虫卵不能孵化出毛蚴； 三氯苯哒唑对人体大片形吸虫成虫和虫卵可能均有杀灭作用， 具有疗效好， 疗程短， 无明显不良反应的特点。

关键词: 大片形吸虫； 阿苯达唑； 三氯苯哒唑； 驱虫