Abstract:

Objective To understand the epidemiological characteristics of co?infection of HIV and Blastocystis hominis and its risk factors. Methods A total of 309 people with HIV positive in the development zone of Fuyang City were recruited，and the face to face questionnaires were conducted to collect the information of behavioral characteristics and sociodemographic data of the participants. Meanwhile，the samples of stool and blood were collected to test B. hominis，cytokines and CD4+ /CD8+ T?lymphocyte. The influencing factors of co?infection of HIV and Blastocystis hominis were analyzed by the single factor analysis and Logistic re? gression analysis. Results Among the 309 people involved，302 accepted feces examinations，286 accepted the questionnaire in? vestigation，and 263 accepted both of them. The infection rate of B. hominis was 17.11%，that of the female was 21.90%，which was significantly higher than that of the male（11.90%） （P < 0.05） . The results from the multivariate Logistic regression model showed that good nutrition was significantly associated with the co?infection of HIV and B. hominis（OR = 0.263，95% CI：0.073， 0.945） . Conclusions The infection rate of B. hominis is high in people with HIV positive，and the nutrition situation of individu? als may be one of the important risk factors associated with co?infection.

Key words: HIV； Blastocystis hominis；Co?infection； Risk factor；Fuyang City

摘要：

目的 了解安徽省阜阳市HIV阳性者合并人芽囊原虫感染情况及其影响因素。方法 采用横断面调查的方法对安徽省阜阳市开发区309名HIV阳性者进行问卷调查， 并采集其粪便和血液样本用于人芽囊原虫、 CD4+ T淋巴细胞和细胞因子检测。采用单因素分析和Logistic回归分析对影响HIV和人芽囊原虫合并感染的因素进行分析。结果 在309名参与调查的HIV阳性者中， 302人参与粪样检测， 286人参与问卷调查， 同时参与2项检测者263人。调查发现， HIV阳性者合并人芽囊原虫感染率为17.11%， 其中女性感染率为21.90%， 明显高于男性 （11.90%）（P < 0.05）。在HIV合并人芽囊原虫感染影响因素Logistic回归模型分析中， 仅营养状况良好 （OR = 0.263， 95% CI： 0.073，0.945） 有统计学意义。结论 HIV阳性者合并人芽囊原虫感染率较高， 营养状况好坏可能是影响合并感染的原因之一。

关键词: HIV； 人芽囊原虫； 合并感染； 影响因素； 阜阳市