Abstract:

Objective To study the expression of P?glycoprotein（P?gp）in patients with chronic schistosomiasis and its rela? tionship with gender and age，and to explore its clinical significance. Methods The colonic mucosa specimens of 50 chronic schistosomiasis patients and 4 persons who had a family history of colon cancer but their physical examinations were normal（as a control group）were selected and the expressions of P?gp in the colonic gland of these samples were detected with the immunohisto? chemical staining method. Results Compared with the control group，the mean gray value of the positive particles of P?gp of co? lonic epithelial cells of the chronic schistosomiasis group was significantly reduced（P < 0.05），but positive unit values were signif? icantly increased（P < 0.05），which meant the P?gp expression in colonic gland of the patients with chronic schistosomiasis was significantly increased，but this increase had no relationship with sex and age. Conclusion Chronic schistosomiasis may induce the increase of P?gp expression which may be a compensatory protection mechanism due to the stimulation of schistosome eggs to the colon tissues.

Key words: Chronic schistosomiasis； Colonic gland； P?glycoprotein

摘要：

目的 探讨慢性血吸虫病患者磷酸糖蛋白 （P?gp） 的表达情况及其与性别、 年龄的关系， 并分析其临床意义。方法 选取50例慢性血吸虫病患者及4例有结肠癌家族史但体检正常者的结肠黏膜标本， 采用免疫组织化学染色法检测P? gp在结肠腺中的表达情况。结果 与正常对照者相比， 慢性血吸虫病患者结肠腺上皮细胞P?gp阳性颗粒平均灰度值明显降低 （P < 0.05）， 阳性单位值明显增加 （P < 0.05）， 但慢性血吸虫病患者结肠腺上皮细胞P?gp表达量增加与性别及年龄无关。结论 慢性血吸虫病可诱导结肠腺上皮细胞P?gp表达量增加， 这可能是机体对血吸虫卵长期刺激结肠组织产生的一种代偿性保护机制。

关键词: 慢性血吸虫病； 结肠腺； 磷酸糖蛋白