Abstract:

 Objective  To explore the relationship between tumor necrosis factor-a (TNF-α) lev-
el in the serum of maternal women with intrauterine infection of Toxoplasma gondii and absortion.
Methods  An examination was carried out on TNF-α in maternal sera and DNA of Toxoplasma
gondii in the cervical secretions ,  and the aborted tissues of the abortion group, and the cervical se-
cretions of the control group by ELISA and PCR, respectively. Results   The TNF-α levels in-
creased in the sera of women with intrauterine infection of Toxoplasma before abortion as compared
with those of the control group and those of themselves after abortions. There were high TNF-α levels in the sera of prognostication abortion women with Toxoplasma infection before the anti-Tox-
oplasm,a treatment as compared with those of the control group and those of themselves after the
treatment with azithromycin.  Conclusion   The results suggest that Toxoplasma gondii infection is
an important factor to increase the TNF-a level in maternal serum.

Key words: Toxoplasma gondii infection, Abortion, Tumor necrosis factor-α

摘要：

目的  探讨弓形虫感染流产孕妇血清肿瘤坏死因子一α (TNF-α)水平及其与流产的关系。方法采用聚合酶链反应技术检测流产孕妇下生殖道分泌物和流产胚胎组织的弓形虫DNA，应用双抗体夹心酶联免疫吸附试验定量测定流产孕妇血清TNF-α水平。结果  弓形虫感染的流产孕妇在流产前血清TNF-α水平比正常同孕期孕妇明显升高，也显著高于自身流产后该水平。弓形虫感染的先兆流产患者应用阿奇霉素治疗后血清TNF-α水平明显下降。结论  弓形虫宫内感染可能是引起孕妇流产前血清TNF-a水平异常升高的重要原因。

关键词: 弓形虫感染；流产；肿瘤坏死因子-α