关键词: 血吸虫病；肝纤维化；病理学；发病机制

Abstract: Schistosomiasis is a widely distributed parasitic zoonoses that threatens human's health?and?social?economic?development. China is one of the most endemic countries in the world. Schistosoma egg are mainly lodged in the liver and intestinal tissues. There， the eggs induce a granulomatous host immune response largely characterized by lymphocytes， eosinophils， and alternatively activated macrophages. The process of granuloma formation induces chronic inflammation that leads to liver fibrosis accompanied by obvious manifestations such as hepatosplenomegaly and ascites. In this article， we reviewed the advanced progress in research about advanced schistosomiasis， including the pathology of liver fibrosis， the formation and modulation of granuloma and fibrosis， the key inflammatory factors and related signaling pathways， the regulatory role of ncRNA in the process of fibrosis， and anti?fibrosis treatment and new drugs development.?

Key words: Schistosomiasis； Liver fibrosis； Pathology； Pathogenesis