Abstract:

To deeply study the molecular mechanism of infection and reproduction of malaria parasites，this review began with co?relationship between toll like receptors（TLRs）and the parasites，further discussed how the parasites were recognized by TLRs and activated downstream inflammation reactions when the mechanical barrier of host was broken through. Some large mole? cules involved into the process had the potential to be novel drug targets.

Key words: Malaria；Malaria parasite； Invasion； Toll like receptors

摘要：

为深入了解疟原虫在侵染、 繁殖过程中的分子机制， 本综述从Toll样受体 （Toll?like receptor，TLR） 与疟原虫的相互作用关系入手， 探讨疟原虫在突破机体防御屏障后如何被TLR识别， 并启动下游炎症反应的机制。其中涉及到的部分重要结构保守的生物大分子有成为新型药物靶分子的潜在特性。

关键词: 疟疾； 疟原虫； 侵染； Toll样受体