Chin J Schisto Control ›› 2011, Vol. 23 ›› Issue (4): 460-464.

Previous Articles     Next Articles

Advances in research of dihydroartemisinin against parasitic diseases

Li Hong-jun, Wang Wei, Liang You-sheng*   

  1. Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial key Laboratory on Molecular Biology of Parasites, Wuxi 214064, China
  • Online:2011-08-15 Published:2011-08-05
  • Contact: Liang You-sheng

双氢青蒿素抗寄生虫作用研究进展

李洪军|汪伟|梁幼生*   

  1. 江苏省血吸虫病防治研究所、卫生部寄生虫病预防与控制技术重点实验室、江苏省寄生虫分子生物学重点实验室(无锡 214064)
  • 通讯作者: 梁幼生
  • 作者简介:李洪军|硕士|助理研究员。研究方向:抗血吸虫药物与寄生虫分子生物学
  • 基金资助:

    国家科技支撑计划(2009BAI78B06);江苏省卫生厅项目(X2009011、X200912);江苏省预防医学研究课题(Y201031)

Abstract:

Dihydroartemisinin, the main metabolite of artemisinin and of two artemisinin derivatives, artemether and artesunate, is a broad-spectrum anti-parasitic drug. The present paper systematically reviews the advances in research of dihydroartemisinin against malaria, Schistosoma, Pneumocystis, Toxoplasma, Trichomonas vaginalis, Leishmania, Giardia lamblia.

Key words: Dihydroartemisinin, Protozoan, Schistosome, Anti-parasitic activity

摘要:

双氢青蒿素是青蒿素及其衍生物蒿甲醚和青蒿琥酯在体内的有效活性代谢产物,为广谱抗寄生虫药物。本文系统综述其抗疟疾、血吸虫、肺孢子虫、弓形虫、阴道毛滴虫、利什曼原虫、蓝氏贾第鞭毛虫作用。

关键词: 双氢青蒿素, 原虫, 血吸虫, 抗寄生虫作用

CLC Number: