Chin J Schisto Control ›› 2020, Vol. 32 ›› Issue (2): 154-.

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Clinical characteristics and distribution of peripheral T lymphocyte subsets in patients with schistosomal hepatic diseases in Suzhou City

YAO Yun-Hai, ZHAO Wei-Feng, GAN Jian-He*   

  1. Department of Infectious Diseases/Intensive Care Unit of Hepatology, The First Hospital Affiliated of Soochow University, Suzhou 215006, China
  • Online:2020-04-30 Published:2020-04-30

苏州地区血吸虫性肝病患者临床特征 及外周血T淋巴细胞亚群分布

姚运海,赵卫峰,甘建和*   

  1. 苏州大学附属第一医院感染科/肝病ICU(苏州215006)
  • 作者简介:姚运海,男,硕士,主治医师。研究方向:肝脏疾病

Abstract: Objective To investigate the clinical characteristics and the distribution of peripheral blood T lymphocyte subsets in patients with schistosomal hepatic cirrhosis in Suzhou City. Methods A total of 32 inpatients with liver diseases due to advanced schistosomiasis at the Department of Infectious Diseases, The First Affiliated Hospital of Soochow University from January 2016 to January 2018 were recruited and assigned into the infection and non?infection groups according to presence of co?infections, and 20 old healthy volunteers served as controls. Venous blood samples were collected on the day of admission, and the proportions of CD4+ T cells, CD8+ T cells, regulatory T (Treg) cells and Th17 cells were detected in peripheral blood using flow cytometry. Results Most patients with liver disorders due to advanced schistosomiasis were admitted to hospital in Suzhou City because of portal hypertension?associated complications, with a high prevalence of co?infections (59.38%, 19/32). The proportions of peripheral CD4+ and CD8+ T cells and Th17 cells were all significantly lower in patients with liver disorders due to advanced schistosomiasis than in controls (t = -5.111, -4.470 and -2.749, all P < 0.05), and a higher proportion of Treg cells was detected in patients than in controls (t = 5.628, P < 0.05). In addition, there were significant differences among the infection group, non?infection group and controls in terms of the percentage of CD4+ T cells, CD8+ T cells, Th17 cells and Treg cells (F = 15.837, 16.594, 9.290 and 27.866, all P < 0.05). Conclusion Portal hypertension?associated complications are predominantly seen in patients with liver diseases due to advanced schistosomiasis at admission in Suzhou City, and co?infections are common. Imbalance of peripheral T cell subsets is detected in patients with liver diseases due to advanced schistosomiasis in Suzhou City.

Key words: Schistosomal liver disease, Clinical characteristic, T lymphocyte subsets, Suzhou City

摘要: 目的 了解苏州地区晚期血吸虫病肝病患者临床特征及其外周血T淋巴细胞亚群分布。方法 以2016年1月-2018年1月在苏州大学附属第一医院感染科住院治疗的32例晚期血吸虫病肝病患者为研究对象,并根据是否合并其他感染分组进行研究;同时随机选取20例老年健康体检者为对照。采集研究对象静脉血,采用流式细胞术检测外周血CD4+ T细胞、CD8+ T细胞、调节性T(Treg)细胞和Th17细胞比例。结果 苏州地区血吸虫性肝病患者多因门脉高压相关并发症入院,合并感染率较高(59.38%,19/32)。血吸虫性肝病患者外周血CD4+ T、CD8+ T淋巴细胞及Th17细胞百分比低于健康对照组(t = –5.111、-4.470和-2.749,P均< 0.05);Treg细胞百分比高于健康对照组(t = 5.628,P < 0.05)。有感染组、无感染组及对照组患者的CD4+ T、CD8+ T淋巴细胞、Th17细胞及Treg细胞亚群分布差异均有统计学意义(F = 15.837、16.594、9.290和27.866,P均< 0.05)。结论 苏州地区血吸虫性肝病患者入院多以门脉高压相关并发症多见,合并感染者较常见,且患者外周血T淋巴细胞亚群已处于失衡状态。

关键词: 血吸虫病肝病, 临床特征, T淋巴细胞亚群, 苏州地区

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