Chinese Journal of Schistosomiasis Control ›› 2022, Vol. 34 ›› Issue (3): 223-.

Previous Articles     Next Articles

Decoding the evolution of preventive chemotherapy schemes for schistosomiasis in China to improve the precise implementation of the WHO guideline on control and elimination of human schistosomiasis

XU Jing1, LI Yi⁃feng2, DONG Yi3, ZHAO Zheng⁃yuan4, WEN Li⁃yong5, ZHANG Shi⁃qing6, LIN Dan⁃dan2, ZHOU Jie4, LIANG Song7, GUO Jia⁃gang8, LI Shi⁃zhu1, ZHOU Xiao⁃nong1*   

  1. 1 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Committee Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai 200025, China; 2 Jiangxi Provincial Institute of Parasitic Diseases, China; 3 Yunnan Provincial Institute of Endemic Diseases, China; 4 Hunan Provincial Institute of Schistosomiasis Control, China; 5 Hangzhou Medical College, Zhejiang Center for Schistosomiasis Control, China; 6 Anhui Provincial Institute of Schistosomiasis Control, China; 7 University of Florida, USA; 8 Department of Control of Neglected Tropical Diseases, World Health Organization, Switzerland
  • Online:2022-07-06 Published:2022-07-06

解析中国血吸虫病预防性化疗方案演变历史 提升WHO指南精准化实施水平

许静1,李宜锋2,董毅3,赵正元4,闻礼永5,张世清6,林丹丹2,周杰4, 梁松7,郭家钢8,李石柱1,周晓农1*   

  1. 1 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、WHO热带病合作中心、国家级热带病国际联合研究中心(上海 200025);2 江西省寄生虫病防治研究所;3 云南省地方病防治所;4 湖南省血吸虫病防治所;5 杭州医学院、浙江省血吸虫病防治中心;6 安徽省血吸虫病防治研究所;7 美国佛罗里达大学;8 WHO被忽视热带病控制司
  • 作者简介:许静,女,博士,研究员。研究方向:血吸虫病流行病学
  • 基金资助:
    国家自然科学基金(82073619);国家重点研发计划(2021YFC2300800、2021YFC2300804)

Abstract: Preventive chemotherapy is one of the pivotal interventions for the control and elimination of schistosomiasis, which is effective to reduce the morbidity and prevalence of schistosomiasis. In order to promote the United Nations’ sustainable development goals and the targets set for schistosomiasis control in the Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021—2030, WHO released the guideline on control and elimination of human schistosomiasis in 2022, with major evidence⁃based updates of the current preventive chemotherapy strategy for schistosomiasis. In China where great success has been achieved in schistosomiasis control, the preventive chemotherapy strategy for schistosomiasis has been updated several times during the past seven decades. This article reviews the evolution of the WHO guidelines on preventive chemotherapy and Chinese national preventive chemotherapy schemes, compares the current Chinese national preventive chemotherapy scheme and the recommendations for preventive chemotherapy proposed in the 2022 WHO guideline on control and elimination of human schistosomiasis, and proposes recommendations for preventive chemotherapy during the future implementation of the 2022 WHO guideline, so as to provide insights into schistosomiasis control among public health professionals engaging in healthcare foreign aid.

Key words: Schistosomiasis, Elimination, Guideline, Preventive chemotherapy, Praziquantel

摘要: 预防性化疗是控制和消除血吸虫病的重要干预措施之一,可显著降低发病率和感染率。为推进联合国可持续发展目标和WHO《结束忽视,实现可持续发展目标:2021—2030年被忽视热带病路线图》中设定的血吸虫病防控目标,2022年WHO发布了《WHO控制和消除人体血吸虫病指南》,基于循证医学证据对血吸虫病化疗策略进行了较大调整。作为血吸虫病防控进程较快的流行国家,中国在70余年的血吸虫病防治历程中对化疗方案也进行了多次调整和修订。本文在回顾WHO和中国血吸虫病化疗策略演变过程的基础上,对中国现行化疗方案和《WHO控制和消除人体血吸虫病指南》中的化疗建议进行了比较分析,并对今后贯彻实施WHO指南的化疗策略提出相应建议,为从事血吸虫病公共卫生援外工作者和相关人员提供参考。

关键词: 血吸虫病, 消除, 指南, 预防性化疗, 吡喹酮

CLC Number: