Chinese Journal of Schistosomiasis Control ›› 2021, Vol. 33 ›› Issue (6): 639-.

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Impact of Toxoplasma gondii human infections on blood lipid levels

WU Li⁃feng*, YE Xu⁃fang   

  1. Department of Laboratory Medicine, The First People’s Hospital of Linping District, Hangzohu City, Hangzhou, Zhejiang 311100, China
  • Online:2022-01-12 Published:2022-01-27

人体刚地弓形虫感染对血脂水平的影响

吴力丰*,叶旭芳   

  1. 浙江省杭州市临平区第一人民医院检验科(浙江 杭州 311100)
  • 作者简介:吴力丰,男,主管检验师。研究方向:临床检验

Abstract: Objective To evaluate the impact of Toxoplasma gondii human infections on blood lipid levels. Methods A total of 1 000 healthy volunteers that were randomly sampled from a tertiary hospital during the period from December 2017 through December 2019 were enrolled, and assigned into the infection group and the control group according to the detection of serum anti⁃T. gondii antibody using enzyme⁃linked immunosorbent assay (ELISA). The serum levels of total cholesterol (TC), high⁃density lipoprotein (HDL), low⁃density lipoprotein (LDL) and triglyceride (TG) were detected and compared between the two groups. Results The seroprevalence of anti⁃T. gondii antibody was 8.40% in the study subjects, and there were no significant differences between the infection and control groups in terms of gender ([χ2] = 1.29, P > 0.05) or age ([χ2] = 1.41, P > 0.05). The mean serum LDL (t = 3.89, P < 0.05) and TC levels (t = 3.81, P < 0.05) were significantly higher in the infection group than in the control group, while no significant differences were seen between the two groups in terms of mean serum TG (t = 0.97, P > 0.05) or HDL levels (t = 0.75, P > 0.05). In addition, the proportions of abnormal LDL ([χ2] = 9.69, P < 0.01) and TC levels ([χ2] = 10.39, P < 0.01) were significantly greater in the infection group than in the control group, while no significant differences were found in the proportion of abnormal TG ([χ2] = 0.02, P > 0.05) or HDL level ([χ2] = 0.11, P > 0.05) between the two groups. Conclusion T. gondii human infections affect blood lipid levels, and the individuals sero⁃positive for anti⁃T. gondii antibody have higher mean serum LDL and TC, as well as higher proportions of abnormal TC and LDL than sero⁃negative individuals.

Key words: Toxoplasma gondii, Blood lipid, Total cholesterol, High?density lipoprotein, Low?density lipoprotein, Triglyceride

摘要: 目的 分析人体刚地弓形虫感染对血脂水平的影响。方法 以2017年1月至2019年12月某三级医院1 000例体检健康者作为研究对象,根据酶联免疫吸附试验(enzyme⁃linked immunosorbent assay, ELISA)是否检出血清抗弓形虫抗体分为感染组和对照组,检测并比较两组研究对象血清总胆固醇(total cholesterol, TC)、高密度脂蛋白(high⁃density lipoprotein, HDL)、低密度脂蛋白(low⁃density lipoprotein, LDL)和甘油三酯(triglyceride, TG)水平。结果 1 000例研究对象血清抗弓形虫抗体阳性率为8.40%,感染组和对照组研究对象性别([χ2] = 1.29,P > 0.05)和年龄构成([χ2] = 1.41,P > 0.05)差异均无统计学意义。感染组研究对象血清LDL和TC均值显著高于对照组(t = 3.89、3.81,P均< 0.05),但两组研究对象血清TG和HDL差异均无统计学意义(t = 0.97、0.75,P均> 0.05);感染组研究对象LDL和TC值不正常比例均显著高于对照组([χ2] = 9.69、10.39,P均< 0.01),但两组研究对象TG和HDL值不正常比例差异均无统计学意义([χ2] = 0.02、0.11,P均> 0.05)。结论 人体刚地弓形虫感染影响血脂水平变化,血清抗弓形虫抗体阳性者平均LDL和TC值及TC和LDL值不正常比例均显著高于抗体阴性者。  

关键词: 刚地弓形虫, 血脂, 总胆固醇, 高密度脂蛋白, 低密度脂蛋白, 甘油三酯

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