Chin J Schisto Control ›› 2020, Vol. 32 ›› Issue (6): 577-.

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Prevalence and risk factors of Blastocystis hominis infections among AIDS patients in Nanchang City

HU Zhu-Hua1, CHEN Hui-Hui2△, QIAN Ke1, NING Chao-Qun2, PENG Guo-Hua1, YU Ying-Fang2, ZHOU Xian-Feng1, CHU Yan-Hong2, XU Dan1, CHEN Jia-Xu2, TIAN Li-Guang2*, LI Hui3*   

  1. 1 Research Base of the National Key Laboratory of Infectious Disease Prevention and Control, Key Laboratory of Animal Origin and Vector?borne Infectious Diseases of Jiangxi Province, Nanchang Center for Disease Control and Prevention, Jiangxi Province, Nanchang 330038, China; 2 National Institute of Parasitic Disease, Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Disease Research, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Key Laboratory of Parasites and Vector Biology, National Health Commission, China; 3 Nanchang Municipal Health Commission, Jiangxi Province, China
  • Online:2020-12-08 Published:2020-12-08

南昌市艾滋病患者合并人芽囊原虫感染情况及危险因素分析

胡主花1,陈慧慧2△,钱科1,宁超群2,彭国华1,俞英昉2,周显凤1,储言红2, 徐丹1,陈家旭2,田利光2*,李辉3*   

  1. 1 传染病预防控制国家重点实验室研究基地、江西省动物源与媒介生物性传染病重点实验室、江西省南昌市疾病预防控制中心(南昌 330038);2中国疾病预防控制中心寄生虫病预防控制所、WHO热带病合作中心、科技部国家级热带病国际联合研究中心、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室;3 江西省南昌市卫生健康委员会
  • 作者简介:胡主花,女,本科,副主任技师。研究方向:寄生虫病防治 陈慧慧,女,硕士研究生。研究方向:寄生虫病流行病学
  • 基金资助:
    国家自然科学基金(81473022);江西省科技厅重点研发项目(20192BBGL70008);江西省卫生计生委科技计划(20186023)

Abstract: Objective To investigate the prevalence and risk factors of Blastocystis hominis infections among AIDS patients in Nanchang City. Methods A cross?sectional questionnaire survey was conducted among AIDS patients in Nanchang City during the period between May and September, 2016. B. hominis infection was detected in patients’ stool samples using a PCR assay, and the CD4+ T cell count was measured in subjects’ blood samples. In addition, the risk factors of B. hominis infection in AIDS patients were identified using univariate and multivariate logistic regression analyses. Results A survey was conducted in Nanchang City from May to September 2016. A total of 505 AIDS patients were investigated, and the prevalence of B. hominis infection was 4.16%. Univariate analysis revealed that B. hominis infection correlated with the occupation ([χ2] = 8.595, P = 0.049), education level ([χ2] = 14.494, P = 0.001), type of daily drinking water ([χ2] = 10.750 , P = 0.020), root of HIV infections ([χ2] = 8.755, P = 0.026) and receiving anti?HIV therapy ([χ2] = 23.083, P = 0.001) among AIDS patients, and multivariate logistic regression analysis identified daily direct drinking of tap water as a risk factor of B. hominis infections [odds ratio (OR) = 7.988, 95% confidential interval (CI): (1.160, 55.004)] and anti?HIV therapy as a protective factor of B. hominis infection [OR = 0.183, 95% CI: (0.049, 0.685)]. Conclusions The prevalence of B. hominis is 4.16% among AIDS patients in Nanchang City. Daily direct drinking of tap water is a risk factor, and anti?HIV therapy is a protective factor of B. hominis infection among AIDS patients living in Nanchang City.

Key words: Blastocystis hominis, AIDS, Co?infection, Risk factor, Nanchang City

摘要: 目的 了解江西省南昌市艾滋病患者人芽囊原虫感染状况及其危险因素。方法 2016年5—9月采用横断面调查法对南昌市艾滋病患者进行问卷调查,并采集调查对象粪便,采用PCR法检测粪便基因组中人芽囊原虫DNA以判定感染状况;同时采集调查对象血液样本,检测其中CD4+ T淋巴细胞数量。采用单因素分析和多因素logistic回归分析对南昌市艾滋病患者人芽囊原虫感染的危险因素进行分析。结果 2016年5—9月在南昌市累计调查艾滋病患者505例,人芽囊原虫感染率为4.16%。单因素分析结果显示,与南昌市艾滋病患者感染人芽囊原虫有关的危险因素包括职业([χ2] = 8.595,P = 0.049)、受教育程度([χ2] = 14.494,P = 0.001)、日常饮用水类型([χ2] = 10.750,P = 0.020)、感染HIV途径([χ2] = 8.755,P = 0.026)、是否接受抗HIV治疗([χ2] = 23.083,P = 0.001);多因素logistic回归分析显示,日常直接饮用自来水是南昌市艾滋病患者感染人芽囊原虫的危险因素[比值比(odds ratio,OR) = 7.988,95%可信区间(confidential interval,CI):(1.160,55.004)],接受抗HIV病毒治疗是人芽囊原虫感染的保护因素[OR = 0.183,95% CI:(0.049,0.685)]。结论 南昌市艾滋病患者人芽囊原虫感染率为4.16%。日常直接饮用自来水是南昌市艾滋病患者感染人芽囊原虫的危险因素,接受抗HIV治疗是保护因素。

关键词: 人芽囊原虫, 艾滋病, 合并感染, 危险因素, 南昌市

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