Chin J Schisto Control ›› 2019, Vol. 31 ›› Issue (5): 498-.

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Epidemiological characteristics and risk factors of Blastocystis hominis infection among patients with HIV/AIDS in Fuyang City, Anhui Province

ZHANG Shun-Xian1, YU Ying-Fang1,WU Xiu-Ping2, CHU Yan-Hong1, TENG Xue-Jiao1, WANG Feng-Feng2, CHEN Jia-Xu1, TIAN Li-Guang1*   

  1. 1 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, National Research Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health Commission, WHO Collaborating Center for Tropical Diseases, Shanghai 200025, China; 2 Anhui Institute of Parasitic Diseases, China
  • Online:2019-11-04 Published:2019-11-05

安徽省阜阳市HIV/AIDS患者人芽囊原虫感染 流行特征及危险因素

张顺先1,俞英昉1,吴秀萍1,储言红1,滕雪娇1,汪峰峰2,陈家旭1,田利光1*   

  1. 1 中国疾病预防控制中心寄生虫病预防控制、国家热带病研究中心、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、世界卫生组织热带病合作中心(上海 200025);2 安徽省血吸虫病防治研究所
  • 作者简介:张顺先,男,博士,助理研究员。研究方向:流行病学与卫生统计学
  • 基金资助:
    国家自然科学基金(81473022);中国博士后科学基金(2018M643043)

Abstract: Objective To investigate the prevalence and risk factors of Blastocystis hominis infections among patients with HIV/AIDS in Fuyang City, Anhui Province. Methods A cross?sectional study was conducted in Fuyang City, Anhui Province in 2016. The demographic and socioeconomic status, and the lifestyle and production style were collected using a questionnaire survey. B. hominis DNA was detected in subjects’ stool samples using a PCR assay, and the CD4+ T lymphocyte count and HIV viral load were measured in the subjects’ blood samples. The risk factors of B. hominis infections among patients with HIV/AIDS were identified using univariate and multivariate logistic regression analyses. Results A total of 398 HIV/AIDS patients were enrolled in this study, with a mean age of 49.3 years, a mean body weight of 55.9 kg and a mean height of 164.4 cm. The prevalence of B. hominis infection was 6.78% in the study subjects, and no gender? ([χ2] = 1.589, P = 0.207), education level? ([χ2] = 0.508, P = 0.776), marital status? ([χ2] = 0.419, P = 0.811) or occupation?specific prevalence ([χ2] = 2.744, P = 0.615) was detected. Among the patients with HIV/AIDS, there were no significant differences in the age (t = 0.370, P = 0.712), height (t = 1.587, P = 0.113), body weight (t = 0.516, P = 0.606), CD4+ T lymphocyte count (t = 1.187, P = 0.230) or HIV viral load (t = 0.193, P = 0.496) between B. hominis?infected and uninfected individuals. Dinking non?tap water [OR = 6.554, 95% CI: (1.876 to 22.903)] and keeping dogs [OR = 5.895, 95% CI: (2.017 to 17.225)] were identified as risk factors for B. hominis infection in patients with HIV/AIDS. Conclusion The prevalence of B. hominis infection is high in HIV/AIDS patients, and drinking non?tap water and keeping dogs are risk factors for B. hominis infection among HIV/AIDS patients.

Key words: Blastocystis hominis, HIV/AIDS, Co?infection, Risk factor, Fuyang City

摘要: 目的 调查安徽省阜阳市HIV/AIDS患者人芽囊原虫感染情况及其危险因素。方法 2016年采用横断面调查方法对安徽省阜阳市HIV/AIDS感染者进行问卷调查,收集调查对象一般人口学信息、社会经济状况、生产生活方式信息。采集调查对象粪便,通过PCR方法检测粪便基因组中人芽囊原虫DNA以判定感染状况;同时采集调查对象血液,检测其中CD4+T淋巴细胞数量和HIV病毒载量。采用单因素分析和多因素logistic回归分析对HIV/AIDS患者人芽囊原虫感染的危险因素进行分析。结果 本研究共招募398名HIV/AIDS病例,平均年龄为49.3岁、平均体重为55.9 kg、平均身高为164.4 cm。人芽囊原虫感染率为6.78%,不同性别([χ2] = 1.589,P = 0.207)、受教育程度([χ2] = 0.508,P = 0.776)、婚姻([χ2] = 0.419,P = 0.811)和职业([χ2] = 2.744,P = 0.615)患者感染率差异均无统计学意义。人芽囊原虫感染者和非感染者年龄(t = 0.370,P = 0.712)、身高(t = 1.587,P = 0.113)、体重(t = 0.516,P = 0.606)、CD4+ T淋巴细胞数量(t = 1.187,P = 0.230)和HIV病毒载量(t = 0.193,P = 0.496)差异均无统计学意义。饮用非自来水[OR = 6.554, 95% CI:(1.876,22.903)]和养狗[OR = 5.895,95% CI:(2.017,17.225)]是HIV/AIDS患者感染人芽囊原虫的危险因素。结论 安徽省阜阳市HIV/AIDS患者人芽囊原虫感染率较高,饮用非自来水和养狗是该人群人芽囊原虫感染的危险因素。

关键词: 人芽囊原虫, HIV/AIDS, 共感染, 危险因素, 阜阳市

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