Chin J Schisto Control ›› 2019, Vol. 31 ›› Issue (3): 346-.

Previous Articles    

Progress of researches on genes associated with sulfadoxine?pyrimethamine resistance in Plasmodium vivax

ZOU Qi-Cheng, LU Feng*   

  1. Department of Parasitology, Medical School, Yangzhou University, Yangzhou 225001, China
  • Online:2019-08-28 Published:2019-08-28

间日疟原虫对磺胺多辛?乙胺嘧啶抗药性 相关基因的研究进展


  1. 扬州大学医学院寄生虫学教研室(扬州225001)
  • 作者简介:邹其成,男,本科生。研究方向:抗疟药物筛选及相关机制
  • 基金资助:

Abstract: Malaria is a parasitic disease which threatens human life and health seriously. Sulfadoxine?pyrimethamine (SP) has been recommended for intermittent preventive treatment of malaria in children and pregnant women, and also used as a compound component of artemisinin based therapy. The mechanisms of SP resistance in P. falciparum involve point mutations in the genes encoding dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS), and the drug pressure can also lead to the mutations in the two genes of P. vivax. To provide the information for the formulation of anti?malarial strategies, this article reviews the discovery, application, effect of SP, and the resistance mechanism and research progress of the related genes in P. vivax.

Key words: Plasmodium vivax, Sulfadoxine?pyrimethamine, Dihydrofolate reductase, Dihydropteroate synthase, Drug resistance

摘要: 疟疾是一种严重威胁人类生命健康的寄生虫病。磺胺多辛?乙胺嘧啶可用于儿童和孕妇疟疾间歇性预防性治疗,同时其也作为以青蒿素及其衍生物为基础的联合疗法的一种复方成分而被用于疟疾治疗。恶性疟原虫对磺胺多辛?乙胺嘧啶产生抗药性与编码二氢叶酸还原酶(DHPS)和二氢蝶酸合酶(DHFR)的基因发生点突变相关,而药物选择压力亦可导致间日疟原虫上述两个基因发生突变。本文就抗疟药磺胺多辛?乙胺嘧啶的发现、应用、作用和间日疟原虫对其抗性机制及抗性相关基因研究进展作一综述,旨在为抗疟策略的制定提供参考依据。

关键词: 间日疟原虫, 磺胺多辛?乙胺嘧啶, 二氢叶酸还原酶, 二氢蝶酸合酶, 抗药性

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