Abstract: Objective To observe the changes of inflammatory factors after the hepatic cystic echinococcosis surgery and explore the intervention effect of ulinastatin on postoperative inflammatory factors. Methods Sixty patients with hepatic cystic echinococcosis were selected and randomly divided into a control group and ulinastatin intervention group according to whether or not use ulinastatin. The peripheral venous bloods were extracted in all the patients and the levels of IL?6， IL?8， IL?9， and IL?10 were detected by the ELISA method on the day before operation， 1 day， 3 days， 5 days and 7 days after operation， respectively. The data was statistical analyzed to detect the relationships between/among the inflammatory factors mentioned above and ulinastatin and time. Results The variation of the levels of IL?6， IL?8， IL?9， and IL?10 were changed by the intervention of ulinastatin at different time. The differences of the levels of IL?6， IL?8， IL?9， and IL?10 between the ulinastatin intervention group and the control group were not significant on the day before operation， 1 day and 3 days after operation （t = -1.15 to 1.82， all P > 0.05）， but the levels of IL?6， IL?8， IL?9， and IL?10 of the ulinastatin intervention group were significantly lower than those of the control group and there were statistically significant differences 5 days and 7 days after the operation （t = 3.22 and 23.51， both P < 0.05）. Conclusion Ulinastatin has a good effect in inhibiting the inflammatory factors and can protect and repair the postoperative hepatic injury as well in patients with hepatic cystic echinococcosis.

Key words: Hepatic cystic echinococcosis, Ulinastatin, Inflammatory factor, Qinghai area

摘要： 目的 观察青海地区肝细粒棘球蚴病患者术后炎性因子变化，评价乌司他丁对肝棘球蚴病患者术后炎性因子的干预作用。方法 选取60例肝细粒棘球蚴病患者，随机分为两组，干预组术后使用乌司他丁，对照组不使用。所有患者于术前、术后第1、3、5天及第7天抽取外周静脉血，应用酶联免疫吸附试验（ELISA）检测白细胞介素?6（IL?6）、IL?8、IL?9、IL?10含量，并分析乌司他丁干预的效果。结果 乌司他丁干预组术后不同时间点IL?6、IL?8、IL?9和IL?10水平变化趋势不同。乌司他丁干预组IL?6、IL?8、IL?9、IL?10水平与对照组在术前、术后第1、3天比较差异均无统计学意义（t = -1.15 ~ 1.82，P均> 0.05）；而在术后第5、7 天低于对照组，差异均有统计学意义（t = 3.22、23.51，P均< 0.05）。结论 乌司他丁在抑制肝细粒棘球蚴病患者机体炎症因子方面有很好效果，对术后肝损伤可以起到保护和治疗作用。　

关键词: 肝细粒棘球蚴病, 乌司他丁, 炎性因子, 青海地区