Chin J Schisto Control ›› 2018, Vol. 30 ›› Issue (5): 596-600.

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Advances in the regulatory roles of exosomes on pathological process of schistosomiasis hepatic fibrosis

ZHOU Yong-hua1*| TANG Xian-shi1| SHEN Li-juan2*| DONG Xuan1| WANG Ke2| YANG Jun-Qi1| XU Yong-liang1   

  1. 1 Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention| Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology| Jiangsu Institute of Parasitic Diseases| Wuxi 214064| China; 2 Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine| China
  • Online:2018-12-01 Published:2018-12-01
  • Contact: ZHOU Yong?hua, SHEN Li?juan

外泌体对血吸虫病肝纤维化病理进程的调节作用研究进展

周永华1*|汤宪时1|沈丽娟2*|董萱1|王珂2|杨俊齐1|许永良1   

  1. 1国家卫生和计划生育委员会寄生虫病预防与控制技术重点实验室、江苏省寄生虫与媒介控制技术重点实验室、江苏省血吸虫病防治研究所(无锡214064);2南京中医药大学无锡附属医院
  • 通讯作者: 周永华,沈丽娟
  • 作者简介:周永华|男|博士|主任技师。研究方向:寄生虫病防治
  • 基金资助:
    国家自然科学基金面上项目(H81373116);江苏省“科教强卫工程”项目(ZDXKA2016016)

Abstract: Exosomes are a group of membraneous vesicles generated and released by multi?vesicular bodies or cell membranes in a variety of cell types. Acting as important messages between cells, they participate in almost every physiological and pathological process of living organisms. Exosomes contain specific proteins, mRNA, miRNAs, etc. and mediate intercellular communications, signal transductions and gene expressions effectively. Exosomes are involved in the formation of hepatic fibrosis, which is the typical liver pathological change in the progression of schistosomiasis and is caused by the liver repair and (or) regeneration involving inflammation stimulated by exosomes, activated hepatic stellate cells and other related pathways in reaction to the parasite infection. Exosomes could serve as new markers for schistosomiasis hepatic fibrosis diagnosis and potential targets for its treatment. This paper briefly reviews the latest development of studies on the regulatory roles of exosomes in schistosomiasis hepatic fibrosis, so as to provide ideas for searching new treatment targets of the disease.

Key words: Schistosomiasis; Exosome; Hepatic fibrosis; Regulatory role

摘要: 外泌体(Exosome)是一类由多种细胞形成和释放的多囊泡体,或由细胞膜产生的细胞外膜性小泡,是细胞间通信、信号传导和基因调控等信息传递的重要介质,参与几乎所有的病理、生理过程。外泌体含有细胞特异性蛋白、mRNA及miRNAs等成分。血吸虫病肝纤维化是血吸虫病发生发展过程中肝组织的病理学改变,受损的肝细胞通过释放外泌体而触发炎症,激活肝星状细胞等启动修复和(或)再生反应。外泌体参与了血吸虫病肝纤维化的形成,可能成为血吸虫病肝纤维化的新的诊断标志物,以及减轻肝纤维化病理进程的新靶点。本文就近年来有关外泌体对血吸虫病肝纤维化调节作用的研究进行综述,旨在为进一步研究和发现血吸虫病肝纤维化的药物治疗新靶点提供新思路。

关键词: 血吸虫病; 外泌体; 肝纤维化; 调节作用

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