Abstract: Objective To understand the Toxoplasma gondii infection in liver disease patients in Hangzhou City. Methods A total of 1 200 patients with liver diseases were enrolled， including 300 patients with liver cancer， 300 cases with hepatitis B， 300 cases with hepatic fibrosis and 300 cases with fatty degeneration of the liver， while 1 200 healthy people served as controls. The serum anti?T. gondii IgG and IgM antibodies were detected in the subjects using ELISA assay. Results The seropositive rates of anti?T. gondii IgG and IgM antibodies were 24.00% （288/1 200） and 1.17% （14/1 200） in the liver disease patients， and 11.42% （137/1 200） and 1.08% （13/1 200） in the healthy controls， respectively. There was a significant difference in the seropositive rate of anti?T. gondii IgG antibody between the liver disease patients and controls （[χ2] = 65.19， P < 0.01）， and no significant difference was seen in the seropositive rate of anti?T. gondii IgM antibody between the liver disease patients and controls （[χ2] = 0.04， P > 0.05）. The seropositive rates of anti?T. gondii IgG antibody were 26.00%， 25.00%， 23.33% and 21.67% in the patients with liver cancer， hepatitis B， hepatic fibrosis and fatty degeneration of the liver， respectively， and no significant difference was detected among these patients with four types of liver diseases （[χ2] = 1.79， P > 0.05）. Conclusion The seropositive rate of anti?T. gondii IgG antibody is high in liver disease patients in Hangzhou City， and the management and health education of toxoplasmosis should be given to patients with liver diseases.

Key words: Toxoplasma gondii； Liver diseases； Hangzhou City

摘要： 目的 了解杭州市肝病患者弓形虫感染情况，为弓形虫病防治提供参考依据。方法 选择肝癌、乙型肝炎、肝纤维化和肝脂肪变性4类肝脏疾病患者各300例，以1 200例体检健康人群作为对照，检测并比较肝病患者和健康对照人群抗弓形虫IgG和IgM抗体阳性率。结果 1 200例肝病患者中，抗弓形虫IgG抗体阳性288例，阳性率为24.00%；抗弓形虫IgM抗体阳性14例，阳性率为1.17%。1 200例健康对照中，抗弓形虫IgG抗体阳性137例，阳性率为11.42%；抗弓形虫IgM抗体阳性13例，阳性率为1.08%。肝病患者和健康对照抗弓形虫IgG抗体阳性率差异有统计学意义（[χ2] = 65.19，P < 0.01），但两者抗弓形虫IgM抗体阳性率差异无统计学意义（[χ2] = 0.04，P > 0.05）。肝癌、乙型肝炎、肝纤维化和肝脂肪变性患者抗弓形虫IgG抗体阳性率分别为26.00%、25.00%、23.33%和21.67%，差异无统计学意义（[χ2] = 1.79，P > 0.05）。 结论 杭州市肝病患者抗弓形虫IgM抗体阳性率较高，应加强肝病患者弓形虫病防治和健康教育。　

关键词: 刚地弓形虫；肝病；杭州市