Abstract: ATP（Adenosine triphosphate）is an important endogenous damage ? associated molecular pattern（DAMP）. P2X7R is an ATP?gated cation channel. ATP?P2X7R plays a vital role in the pathophysiology of many diseases because P2X7R is distributed on various immune cells. ATP?P2X7R signal transduction pathway has been implicated to participate in the body's im? mune defense against pathogens. This paper reviews the recent progress regarding ATP?P2X7R and its effects on parasitic diseas? es.

Key words: Adenosine triphosphate；P2X7R；Macrophage；Dendritic cell；Proinflammatory mediator；Parasitic disease

摘要： 三磷酸腺苷（Adenosine triphosphate， ATP）是机体内一种重要的内源性损伤相关分子模式（Damage?associated molecular pattern，DAMP）。嘌呤受体P2X7（Purinergic receptor，P2X7R）是以ATP为配体的离子门控通道，在多种疾病的病理生理过程中发挥着重要作用。因P2X7R 表达于多种免疫细胞表面，ATP?P2X7R信号转导途径成为机体对抗病原体的重要组成部分。本文主要就ATP?P2X7R信号通路及其在寄生虫感染中的作用和机制作一综述。 　

关键词: 三磷酸腺苷；嘌呤受体P2X7；巨噬细胞；树突状细胞；促炎因子；寄生虫病