Abstract: Babesia parasites are obligate intracellular apicomplexan protozoa and important pathogens causing babesiosis of humans and animals. They have conserved subcellular structures and invasion mechanism. Rhoptry?associated proteins， which are released into the host cell， are considered to be the key molecules of invasion and replication of parasites in the host cell and are immunosuppressive factors of the host cell mediated immunity in the stage of parasitophorous vacuole （PV） formation. The knowledge about rhoptry?associated proteins has made a great progress with the development of genomics and proteomics， so we review the research progress in rhoptry?associated proteins of different Babesia including Babesia bovis， B. ovine， B. gibsoni， B. bigemina and B. orientalis， etc.

Key words: Babesia； Rhoptry?associated protein； Invasion； Immune

摘要： 巴贝虫是一类专性的细胞内寄生的顶复门原虫，是人和动物的重要病原。这类原虫具有相似的亚细胞结构并能分泌与入侵相关的保守蛋白，尤其是在入侵宿主细胞阶段分泌的棒状体相关蛋白被认为是保护寄生虫入侵和繁殖的关键分子，其在虫体入侵的纳虫空泡形成过程中发挥重要作用。随着基因组学和蛋白质组学技术的不断发展，其相关研究也越来越深入。因此，本文就目前研究较多的牛巴贝虫、羊巴贝虫、吉氏巴贝虫、双芽巴贝虫和东方巴贝虫等棒状体相关蛋白的研究现状进行了综述。

关键词: 巴贝虫；棒状体相关蛋白；入侵；免疫