Chin J Schisto Control ›› 2015, Vol. 27 ›› Issue (1): 56-.

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Effect of calcium cyanamid synthetic drug on Schistosoma japonicum egg morphology

ZHOU Yi-sheng1 |PENG Guo-hua1 | HU Zhu-hua1 |FENG Xiao-wu1 |ZHU Rong2 |WEI Wang-yuan3 |GUO Jia-gang2*   

  1. 1 Nanchang Center for Disease Control and Prevention|Jiangxi Province|Nanchang 330038|China;2 National Institute of Par? asitic Diseases|Chinese Center for Disease Control and Prevention|Key Laboratory of Parasite and Vector Biology|Ministry of Health|WHO Collaborating Centre for Malaria|Schistosomiasis and Filariasis|China;3 Hunan Institute of Parasitic Diseases| China
  • Online:2015-03-05 Published:2015-03-06
  • Contact: GUO Jia?gang

氰氨化钙合成药物对血吸虫虫卵形态学影响

周义生1|彭国华1|胡主花1|冯小武1|朱蓉2|魏望远3|郭家钢2*   

  1. 1南昌市疾病预防控制中心 (南昌 330038); 2中国疾病预防控制中心寄生虫病预防控制所| 卫生部寄生虫病原与媒介生物学重点 实验室| 世界卫生组织疟疾、 血吸虫病和丝虫病合作中心; 3湖南省血吸虫病防治所
  • 通讯作者: 郭家钢
  • 作者简介:周义生| 男| 硕士| 主管医师。研究方向: 血吸虫病控制
  • 基金资助:
    江西省卫生和计划生育委员会项目 (20133191)

Abstract: Objective Objective To study the morphological change of Schistosoma japonicum eggs processed by calcium cyanamide synthetic drug,so as to provide the basis for further study of the mechanism that calcium cyanamide synthetic drug to schisto? some eggs. Methods Methods The calcium cyanamide synthetic drug was added to the cattle feces containing schistosome eggs and mixed up,and then the cattle feces was stacked as original shape on the marshland. Blank controls were set at the same time. The cattle feces samples were collected and the schistosome eggs were observed under a microscope on the 1st,2nd,3rd,7th day after the experiment. Results Results By the effect of calcium cyanamide synthetic drug,the color of eggs was deepening gradual? ly,the miracidia were atrophied,and the shells of eggs were thickened. The embryonic membrane of miracidia was no longer completed 3 days later,and the miracidia were deformed severely 7 days later. The atrophy of miracidia was not obvious in the blank controls. Conclusion Conclusion The schistosome miracidia and embryonic membrane can be damaged by the calcium cyanamide synthetic drug, and worse damaged with time extending.

Key words: Schistosome egg; Calcium cyanamide; Drug; Morphology; Effect

摘要: 目的 目的 观察虫卵经氰氨化钙合成药物作用后的形态改变, 为进一步研究氰氨化钙合成药物杀灭血吸虫虫卵作 用机理提供依据。 方法 方法 向含有血吸虫虫卵的阳性牛粪中加入氰氨化钙合成药物并搅拌, 模拟野粪自然形态堆放于洲 滩上; 同时设空白对照。于1、 2、 3、 7 d后分别取样, 收集血吸虫虫卵, 于显微镜下观察虫卵形态。 结果 结果 虫卵经氰氨化 钙合成药物作用后, 颜色逐步加深, 毛蚴萎缩, 卵壳变厚, 3 d后胚膜不完整, 7 d后毛蚴严重变形; 对照组毛蚴未见明显萎 缩。 结论 结论 氰氨化钙合成药物对虫卵胚膜及毛蚴有损伤作用, 且随时间延长而损伤加重。

关键词: 血吸虫虫卵; 氰氨化钙; 药物; 形态; 影响

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